Coffee consumption attenuates short-term fructose-induced liver insulin resistance in healthy men.

Détails

ID Serval
serval:BIB_C530FAE6FCEC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Coffee consumption attenuates short-term fructose-induced liver insulin resistance in healthy men.
Périodique
American Journal of Clinical Nutrition
Auteur(s)
Lecoultre V., Carrel G., Egli L., Binnert C., Boss A., Macmillan E.L., Kreis R., Boesch C., Darimont C., Tappy L.
ISSN
1938-3207 (Electronic)
ISSN-L
0002-9165
Statut éditorial
Publié
Date de publication
2014
Volume
99
Numéro
2
Pages
268-275
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
BACKGROUND: Epidemiologic and experimental data have suggested that chlorogenic acid, which is a polyphenol contained in green coffee beans, prevents diet-induced hepatic steatosis and insulin resistance.
OBJECTIVE: We assessed whether the consumption of chlorogenic acid-rich coffee attenuates the effects of short-term fructose overfeeding, dietary conditions known to increase intrahepatocellular lipids (IHCLs), and blood triglyceride concentrations and to decrease hepatic insulin sensitivity in healthy humans.
DESIGN: Effects of 3 different coffees were assessed in 10 healthy volunteers in a randomized, controlled, crossover trial. IHCLs, hepatic glucose production (HGP) (by 6,6-d2 glucose dilution), and fasting lipid oxidation were measured after 14 d of consumption of caffeinated coffee high in chlorogenic acid (C-HCA), decaffeinated coffee high in chlorogenic acid, or decaffeinated coffee with regular amounts of chlorogenic acid (D-RCA); during the last 6 d of the study, the weight-maintenance diet of subjects was supplemented with 4 g fructose · kg(-1) · d(-1) (total energy intake ± SD: 143 ± 1% of weight-maintenance requirements). All participants were also studied without coffee supplementation, either with 4 g fructose · kg(-1) · d(-1) (high fructose only) or without high fructose (control).
RESULTS: Compared with the control diet, the high-fructose diet significantly increased IHCLs by 102 ± 36% and HGP by 16 ± 3% and decreased fasting lipid oxidation by 100 ± 29% (all P < 0.05). All 3 coffees significantly decreased HGP. Fasting lipid oxidation increased with C-HCA and D-RCA (P < 0.05). None of the 3 coffees significantly altered IHCLs.
CONCLUSIONS: Coffee consumption attenuates hepatic insulin resistance but not the increase of IHCLs induced by fructose overfeeding. This effect does not appear to be mediated by differences in the caffeine or chlorogenic acid content. This trial was registered at clinicaltrials.gov as NCT00827450.
Pubmed
Web of science
Open Access
Oui
Création de la notice
21/02/2014 19:15
Dernière modification de la notice
09/05/2019 0:59
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