Sequence homologies in the region preceding the transcription initiation site of the liver estrogen-responsive vitellogenin and apo-VLDLII genes.

Détails

ID Serval
serval:BIB_C51475C79C0F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Sequence homologies in the region preceding the transcription initiation site of the liver estrogen-responsive vitellogenin and apo-VLDLII genes.
Périodique
Nucleic Acids Research
Auteur(s)
Walker P., Germond J.E., Brown-Luedi M., Givel F., Wahli W.
ISSN
0305-1048[print], 0305-1048[linking]
Statut éditorial
Publié
Date de publication
11/1984
Volume
12
Numéro
22
Pages
8611-8626
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
In the liver of oviparous vertebrates vitellogenin gene expression is controlled by estrogen. The nucleotide sequence of the 5' flanking region of the Xenopus laevis vitellogenin genes A1, A2, B1 and B2 has been determined. These sequences have been compared to each other and to the equivalent region of the chicken vitellogenin II and apo-VLDLII genes which are also expressed in the liver in response to estrogen. The homology between the 5' flanking region of the Xenopus genes B1 and B2 is higher than between the corresponding regions of the other closely related genes A1 and A2. Four short blocks of sequence homology which are present at equivalent positions in the vitellogenin genes of both Xenopus laevis and chicken are characterized. A short sequence with two-fold rotational symmetry (GGTCANNNTGACC) was found at similar positions upstream of the five vitellogenin genes and is also present in two copies close to the 5' end of the chicken apo-VLDLII gene. The possible functional significance of this sequence, common to liver estrogen-responsive genes, is discussed.
Mots-clé
Animals, Apolipoproteins/genetics, Base Sequence, Chickens, Estradiol/pharmacology, Genes/drug effects, Lipoproteins/genetics, Lipoproteins, VLDL/genetics, Liver/drug effects, Liver/metabolism, Protein Binding, Receptors, Steroid/genetics, Transcription, Genetic, Vitellogenins/genetics, Xenopus
Pubmed
Web of science
Création de la notice
24/01/2008 17:04
Dernière modification de la notice
03/03/2018 21:15
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