Multicentre study of 18F-FDG-PET/CT prostate incidental uptake.

Détails

ID Serval
serval:BIB_C4AC2B34535D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Multicentre study of 18F-FDG-PET/CT prostate incidental uptake.
Périodique
Japanese journal of radiology
Auteur(s)
Bertagna F., Piccardo A., Dib B., Bertoli M., Fracassi F., Bosio G., Giubbini R., Biasiotto G., Giovanella L., Treglia G.
ISSN
1867-108X (Electronic)
ISSN-L
1867-1071
Statut éditorial
Publié
Date de publication
09/2015
Peer-reviewed
Oui
Volume
33
Numéro
9
Pages
538-546
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study
Publication Status: ppublish
Résumé
The purpose of our study was to establish the prevalence and pathological nature of fluorine-18-fluorodeoxyglucose (18F-FDG) prostate incidental uptake (PIU) among patients studied for non-prostate-malignant purposes in three nuclear medicine centres.
We retrospectively evaluated 20,422 scans performed on male patients; all patients underwent 18F-FDG-PET/CT for purposes not related to prostate disease.
Among 20,422 patients PIU was identified for 280 (1.4 %) with an average age of 70 ± 10.7 years. Sixty-three of the 280 patients with PIU (22.5 %) underwent PSA dosage and biopsy to determine the nature of the incidental uptake. Thirty-five of the 63 (55.5 %) PIU were malignant whereas 28/63 (44.5 %) were benign. The average value of PSA for patients with benign PIU was 3.7 ± 2.8 ng/ml whereas it was 7.8 ± 8.2 ng/ml in patients with malignant PIU; this difference was statistically significant. For malignant lesions, the average lesion-to-liver SUVmax ratio was 2.9 ± 2.5 and the average lesion-to-blood-pool SUVmax ratio was 3.7 ± 2.5. For benign lesions, the average lesion-to-liver SUVmax ratio was 2.5 ± 1.7 and the average lesion-to-blood-pool SUVmax ratio was 3.5 ± 2.4; there was no statistically significant difference between lesion-to-liver and lesion-to-blood-pool SUVmax ratios for benign and malignant lesions.
Because PIU values are indicative of malignancy for a substantial percentage of patients, further investigation is required.

Mots-clé
Aged, Fluorodeoxyglucose F18/pharmacokinetics, Humans, Incidental Findings, Male, Middle Aged, Multimodal Imaging, Positron-Emission Tomography, Prostate/diagnostic imaging, Prostatic Neoplasms/diagnosis, Radiopharmaceuticals/pharmacokinetics, Retrospective Studies, Tomography, X-Ray Computed, 18F-FDG, Incidentaloma, PET/CT, Prostate
Pubmed
Web of science
Création de la notice
20/08/2017 17:59
Dernière modification de la notice
03/03/2018 21:14
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