Molecular evolution of juvenile hormone esterase-like proteins in a socially exchanged fluid.

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Etat: Serval
Version: Final published version
ID Serval
serval:BIB_C49E98634123
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Molecular evolution of juvenile hormone esterase-like proteins in a socially exchanged fluid.
Périodique
Scientific Reports
Auteur(s)
LeBoeuf A.C., Cohanim A.B., Stoffel C., Brent C.S., Waridel P., Privman E., Keller L., Benton R.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Statut éditorial
Publié
Date de publication
2018
Peer-reviewed
Oui
Volume
8
Numéro
1
Pages
17830
Langue
anglais
Résumé
Socially exchanged fluids are a direct means by which an organism can influence conspecifics. It was recently shown that when workers of the carpenter ant Camponotus floridanus feed larval offspring via trophallaxis, they transfer Juvenile Hormone III (JH), a key developmental regulator, as well as paralogs of JH esterase (JHE), an enzyme that catalyzes the hydrolysis of JH. Here we combine proteomic, phylogenetic and selection analyses to investigate the evolution of this esterase subfamily. We show that Camponotus JHE-like proteins have undergone multiple duplications, experienced positive selection, and changed tissue localization to become abundantly and selectively present in trophallactic fluid. The Camponotus trophallactic esterases have maintained their catalytic triads and contain a number of positively-selected amino acid changes distributed throughout the protein, which possibly reflect an adaptation to the highly acidic trophallactic fluid of formicine ants. To determine whether these esterases might regulate larval development, we fed workers with a JHE-specific pharmacological inhibitor to introduce it into the trophallactic network. This inhibitor increased the likelihood of pupation of the larvae reared by these workers, similar to the influence of food supplementation with JH. Together, these findings suggest that JHE-like proteins have evolved a new role in the inter-individual regulation of larval development in the Camponotus genus.
Pubmed
Web of science
Open Access
Oui
Création de la notice
01/06/2018 20:43
Dernière modification de la notice
09/05/2019 0:57
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