Comparison of levocabastine, a new selective H1-receptor antagonist, and disodium cromoglycate, in a nasal provocation test with allergen

Détails

ID Serval
serval:BIB_C47C15D361B6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Comparison of levocabastine, a new selective H1-receptor antagonist, and disodium cromoglycate, in a nasal provocation test with allergen
Périodique
British Journal of Clinical Pharmacology
Auteur(s)
Kolly  M., Pecoud  A.
ISSN
0306-5251 (Print)
Statut éditorial
Publié
Date de publication
10/1986
Volume
22
Numéro
4
Pages
389-94
Notes
Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial --- Old month value: Oct
Résumé
The effect of intranasal administration of levocabastine, a new selective H1-receptor antagonist, was investigated in a nasal provocation test (NPT) performed with allergens. The NPT allowed a quantitative estimation of the nasal allergic threshold (concentration of allergen necessary to trigger the reaction). In addition, the intensity of the three major rhinitis symptoms (obstruction, rhinorrhea and sneezing) was determined. Twelve adult patients, allergic to grass pollen, underwent a first NPT without pretreatment ('initial NPT'); the NPT was then repeated after the single intranasal administration of either placebo, 8 mg disodium cromoglycate (DSCG) or 0.2 mg levocabastine in a double-blind random order. The NPTs gave reproducible results since both the threshold and symptom intensities were similar in the initial NPT and in the NPT performed after placebo. The reaction threshold increased in 8/12 patients after DSCG (0.05 less than P less than 0.1) and in 9/12 patients after levocabastine (P less than 0.05). Levocabastine clearly inhibited rhinorrhea (P less than 0.001) and sneezing (P less than 0.02) but did not influence the nasal obstruction. DSCG inhibited rhinorrhea only (P less than 0.01). The intranasal administration of levocabastine might be useful in the treatment of allergic rhinitis.
Mots-clé
Administration, Inhalation Adolescent Adult Allergens/*administration & dosage Child Clinical Trials Cromolyn Sodium/administration & dosage/*pharmacology Double-Blind Method Female Histamine H1 Antagonists/administration & dosage/*pharmacology Humans Male Nasal Mucosa/drug effects/secretion *Nasal Provocation Tests Piperidines/administration & dosage/*pharmacology Sneezing/drug effects
Pubmed
Web of science
Création de la notice
28/01/2008 12:58
Dernière modification de la notice
03/03/2018 21:13
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