MicroRNA-155 Is Required for Effector CD8(+) T Cell Responses to Virus Infection and Cancer.

Détails

Ressource 1Télécharger: 0_23601686_Postprint.pdf (1793.57 [Ko])
Etat: Public
Version: de l'auteur
Document(s) secondaire(s)
Télécharger: 0_23601686_Postprint.pdf (1649.96 [Ko])
Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_C465F0F1D8F8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
MicroRNA-155 Is Required for Effector CD8(+) T Cell Responses to Virus Infection and Cancer.
Périodique
Immunity
Auteur(s)
Dudda J.C., Salaun B., Ji Y., Palmer D.C., Monnot G.C., Merck E., Boudousquie C., Utzschneider D.T., Escobar T.M., Perret R., Muljo S.A., Hebeisen M., Rufer N., Zehn D., Donda A., Restifo N.P., Held W., Gattinoni L., Romero P.
ISSN
1097-4180 (Electronic)
ISSN-L
1074-7613
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
38
Numéro
4
Pages
742-753
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
MicroRNAs (miRNAs) regulate the function of several immune cells, but their role in promoting CD8(+) T cell immunity remains unknown. Here we report that miRNA-155 is required for CD8(+) T cell responses to both virus and cancer. In the absence of miRNA-155, accumulation of effector CD8(+) T cells was severely reduced during acute and chronic viral infections and control of virus replication was impaired. Similarly, Mir155(-/-) CD8(+) T cells were ineffective at controlling tumor growth, whereas miRNA-155 overexpression enhanced the antitumor response. miRNA-155 deficiency resulted in accumulation of suppressor of cytokine signaling-1 (SOCS-1) causing defective cytokine signaling through STAT5. Consistently, enforced expression of SOCS-1 in CD8(+) T cells phenocopied the miRNA-155 deficiency, whereas SOCS-1 silencing augmented tumor destruction. These findings identify miRNA-155 and its target SOCS-1 as key regulators of effector CD8(+) T cells that can be modulated to potentiate immunotherapies for infectious diseases and cancer.
Pubmed
Web of science
Open Access
Oui
Création de la notice
14/05/2013 9:38
Dernière modification de la notice
20/08/2019 16:39
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