JC virus-specific cytotoxic T lymphocytes in individuals with progressive multifocal leukoencephalopathy.

Détails

ID Serval
serval:BIB_C461ED5F2B81
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
JC virus-specific cytotoxic T lymphocytes in individuals with progressive multifocal leukoencephalopathy.
Périodique
Journal of Virology
Auteur(s)
Koralnik I.J., Du Pasquier R.A., Letvin N.L.
ISSN
0022-538X[print], 0022-538X[linking]
Statut éditorial
Publié
Date de publication
2001
Peer-reviewed
Oui
Volume
75
Numéro
7
Pages
3483-3487
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Résumé
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by a reactivation of the polyomavirus JC (JCV) within a setting of immunosuppression. The nature of the immune response that contains replication of this virus is unknown. We have explored JCV-specific cellular immune responses in patients with PML and control subjects. JCV antigen-stimulated peripheral blood mononuclear cells (PBMC) of four human immunodeficiency virus (HIV)-infected patients who were survivors of PML and one HIV-uninfected patient recently diagnosed with PML lysed autologous B-lymphoblastoid cell lines expressing either the JCV T regulatory protein or the VP1 major capsid protein. This lysis was mediated by CD8(+) T lymphocytes and was major histocompatibility complex class I restricted. These cells were therefore cytotoxic T lymphocytes (CTL). JCV-specific CTL could not be detected in PBMC of three HIV-infected PML patients who had progressive neurologic disease and an eventual fatal outcome. These data suggest that the JCV-specific cellular immune response may play a crucial role in the containment of PML. This finding may also prove useful as a favorable prognostic marker in the clinical management of these patients.
Mots-clé
Antigens, Polyomavirus Transforming/immunology, Capsid/immunology, Capsid Proteins, Histocompatibility Antigens Class I/immunology, Humans, JC Virus/immunology, Leukoencephalopathy, Progressive Multifocal/immunology, T-Lymphocytes, Cytotoxic/immunology
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 15:56
Dernière modification de la notice
09/05/2019 0:56
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