Pathogenicity of fibroblast- and lymphocyte-specific variants of minute virus of mice

Détails

ID Serval
serval:BIB_C4577AF9965E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Pathogenicity of fibroblast- and lymphocyte-specific variants of minute virus of mice
Périodique
Journal of Virology
Auteur(s)
Kimsey  P. B., Engers  H. D., Hirt  B., Jongeneel  C. V.
ISSN
0022-538X (Print)
Statut éditorial
Publié
Date de publication
07/1986
Volume
59
Numéro
1
Pages
8-13
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul
Résumé
We tested two strains of the minute virus of mice (MVM) for pathogenic effects and patterns of infection in laboratory mice. The two strains differ in their ability to infect differentiated cultured cells: the prototype virus, MVMp, infects only fibroblasts, while its variant, MVMi, is restricted to lymphocytes. We find that neither strain has any demonstrable effects on the T-cell function of mice infected as adults. In contrast, MVMi, but not MVMp, is able to induce a runting syndrome accompanied by mild immune deficiencies upon the infection of newborn mice. After neonatal infection, MVMi spreads to many organs, and the presence of viral replicative form DNA is evident in nucleic acid hybridization experiments. In contrast, replication of MVMp can be detected only by the seroconversion of infected animals. Newborn mice that grow abnormally as a result of MVMi infection also have low circulating antibody titers to the virus. This phenomenon may be a consequence of the lymphotropism of MVMi.
Mots-clé
Animals Animals, Newborn/microbiology Antibodies, Viral/biosynthesis Fibroblasts/microbiology Hypersensitivity, Delayed/immunology Immunity, Cellular Lymphocytes/microbiology Mice Minute virus of mice/growth & development/*pathogenicity Parvoviridae/*pathogenicity Tissue Distribution Virus Diseases/physiopathology
Pubmed
Web of science
Création de la notice
24/01/2008 16:39
Dernière modification de la notice
03/03/2018 21:13
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