Exposure to hypobaric hypoxia results in higher oxidative stress compared to normobaric hypoxia.
Details
Serval ID
serval:BIB_C44D119F9275
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Exposure to hypobaric hypoxia results in higher oxidative stress compared to normobaric hypoxia.
Journal
Respiratory Physiology and Neurobiology
ISSN
1878-1519 (Electronic)
ISSN-L
1569-9048
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
223
Pages
23-27
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Sixteen healthy exercise trained participants underwent the following three, 10-h exposures in a randomized manner: (1) Hypobaric hypoxia (HH; 3450m terrestrial altitude) (2) Normobaric hypoxia (NH; 3450m simulated altitude) and (3) Normobaric normoxia (NN). Plasma oxidative stress (malondialdehyde, MDA; advanced oxidation protein products, AOPP) and antioxidant markers (superoxide dismutase, SOD; glutathione peroxidase, GPX; catalase; ferric reducing antioxidant power, FRAP) were measured before and after each exposure. MDA was significantly higher after HH compared to NN condition (+24%). SOD and GPX activities were increased (vs. before; +29% and +54%) while FRAP was decreased (vs. before; -34%) only after 10h of HH. AOPP significantly increased after 10h for NH (vs. before; +83%), and HH (vs. before; +99%) whereas it remained stable in NN. These results provide evidence that prooxidant/antioxidant balance was impaired to a greater degree following acute exposure to terrestrial (HH) vs. simulated altitude (NH) and that the chamber confinement (NN) did likely not explain these differences.
Pubmed
Create date
24/03/2016 14:45
Last modification date
20/08/2019 15:39