Exposure to hypobaric hypoxia results in higher oxidative stress compared to normobaric hypoxia.

Détails

ID Serval
serval:BIB_C44D119F9275
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Exposure to hypobaric hypoxia results in higher oxidative stress compared to normobaric hypoxia.
Périodique
Respiratory Physiology and Neurobiology
Auteur(s)
Ribon A., Pialoux V., Saugy J.J., Rupp T., Faiss R., Debevec T., Millet G.P.
ISSN
1878-1519 (Electronic)
ISSN-L
1569-9048
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
223
Pages
23-27
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Sixteen healthy exercise trained participants underwent the following three, 10-h exposures in a randomized manner: (1) Hypobaric hypoxia (HH; 3450m terrestrial altitude) (2) Normobaric hypoxia (NH; 3450m simulated altitude) and (3) Normobaric normoxia (NN). Plasma oxidative stress (malondialdehyde, MDA; advanced oxidation protein products, AOPP) and antioxidant markers (superoxide dismutase, SOD; glutathione peroxidase, GPX; catalase; ferric reducing antioxidant power, FRAP) were measured before and after each exposure. MDA was significantly higher after HH compared to NN condition (+24%). SOD and GPX activities were increased (vs. before; +29% and +54%) while FRAP was decreased (vs. before; -34%) only after 10h of HH. AOPP significantly increased after 10h for NH (vs. before; +83%), and HH (vs. before; +99%) whereas it remained stable in NN. These results provide evidence that prooxidant/antioxidant balance was impaired to a greater degree following acute exposure to terrestrial (HH) vs. simulated altitude (NH) and that the chamber confinement (NN) did likely not explain these differences.
Pubmed
Création de la notice
24/03/2016 15:45
Dernière modification de la notice
03/03/2018 21:13
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