Reduced binding of oxytocin in the rat brain during aging

Détails

ID Serval
serval:BIB_C43F44056893
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Reduced binding of oxytocin in the rat brain during aging
Périodique
Brain Research
Auteur(s)
Arsenijevic  Y., Dreifuss  J. J., Vallet  P., Marguerat  A., Tribollet  E.
ISSN
0006-8993 (Print)
Statut éditorial
Publié
Date de publication
11/1995
Volume
698
Numéro
1-2
Pages
275-9
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Nov 6
Résumé
Central oxytocin (OT) receptors were labelled in 3-month-old and 20-month-old rats with an iodinated OT antagonist. Comparison of the autoradiograms by quantitative image analysis revealed in the old animals a significant reduction of binding in three regions; the number of labelled OT receptors was decreased by 90% in the head of the caudate putamen, by 68% in the olfactory tubercle, and by 41% in the ventromedial hypothalamic nucleus. Previous studies had shown that the expression of OT receptors in the olfactory tubercle and in the ventromedial hypothalamic nucleus was dependent upon gonadal steroids. Therefore we hypothesize that the reduced number of OT receptors in the latter two structures of aged rats was the consequence of the 4-fold decrease of plasma testosterone that we found in this age. Another mechanism may be responsible for the marked reduction of OT receptors in the caudate putamen.
Mots-clé
Aging/*metabolism Animals Autoradiography Brain/*metabolism Male Oxytocin/*metabolism Rats Rats, Sprague-Dawley Receptors, Oxytocin/*metabolism
Pubmed
Web of science
Création de la notice
28/01/2008 13:31
Dernière modification de la notice
03/03/2018 21:13
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