Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes.

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Ressource 1Télécharger: s13059-019-1768-2.pdf (4623.86 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_C423F727BB77
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Compte-rendu: analyse d'une oeuvre publiée.
Collection
Publications
Titre
Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes.
Périodique
Genome biology
Auteur(s)
Attardo G.M., Abd-Alla AMM, Acosta-Serrano A., Allen J.E., Bateta R., Benoit J.B., Bourtzis K., Caers J., Caljon G., Christensen M.B., Farrow D.W., Friedrich M., Hua-Van A., Jennings E.C., Larkin D.M., Lawson D., Lehane M.J., Lenis V.P., Lowy-Gallego E., Macharia R.W., Malacrida A.R., Marco H.G., Masiga D., Maslen G.L., Matetovici I., Meisel R.P., Meki I., Michalkova V., Miller W.J., Minx P., Mireji P.O., Ometto L., Parker A.G., Rio R., Rose C., Rosendale A.J., Rota-Stabelli O., Savini G., Schoofs L., Scolari F., Swain M.T., Takáč P., Tomlinson C., Tsiamis G., Van Den Abbeele J., Vigneron A., Wang J., Warren W.C., Waterhouse R.M., Weirauch M.T., Weiss B.L., Wilson R.K., Zhao X., Aksoy S.
ISSN
1474-760X (Electronic)
ISSN-L
1474-7596
Statut éditorial
Publié
Date de publication
02/09/2019
Peer-reviewed
Oui
Volume
20
Numéro
1
Pages
187
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
Tsetse flies (Glossina sp.) are the vectors of human and animal trypanosomiasis throughout sub-Saharan Africa. Tsetse flies are distinguished from other Diptera by unique adaptations, including lactation and the birthing of live young (obligate viviparity), a vertebrate blood-specific diet by both sexes, and obligate bacterial symbiosis. This work describes the comparative analysis of six Glossina genomes representing three sub-genera: Morsitans (G. morsitans morsitans, G. pallidipes, G. austeni), Palpalis (G. palpalis, G. fuscipes), and Fusca (G. brevipalpis) which represent different habitats, host preferences, and vectorial capacity.
Genomic analyses validate established evolutionary relationships and sub-genera. Syntenic analysis of Glossina relative to Drosophila melanogaster shows reduced structural conservation across the sex-linked X chromosome. Sex-linked scaffolds show increased rates of female-specific gene expression and lower evolutionary rates relative to autosome associated genes. Tsetse-specific genes are enriched in protease, odorant-binding, and helicase activities. Lactation-associated genes are conserved across all Glossina species while male seminal proteins are rapidly evolving. Olfactory and gustatory genes are reduced across the genus relative to other insects. Vision-associated Rhodopsin genes show conservation of motion detection/tracking functions and variance in the Rhodopsin detecting colors in the blue wavelength ranges.
Expanded genomic discoveries reveal the genetics underlying Glossina biology and provide a rich body of knowledge for basic science and disease control. They also provide insight into the evolutionary biology underlying novel adaptations and are relevant to applied aspects of vector control such as trap design and discovery of novel pest and disease control strategies.
Mots-clé
Disease, Hematophagy, Lactation, Neglected, Symbiosis, Trypanosomiasis, Tsetse
Pubmed
Open Access
Oui
Création de la notice
05/09/2019 15:18
Dernière modification de la notice
22/09/2019 7:08
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