Pattern of dopaminergic loss in the striatum of humans with MPTP induced parkinsonism

Détails

ID Serval
serval:BIB_C421A95FD773
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Pattern of dopaminergic loss in the striatum of humans with MPTP induced parkinsonism
Périodique
Journal of Neurology, Neurosurgery and Psychiatry
Auteur(s)
Snow  B. J., Vingerhoets  F. J., Langston  J. W., Tetrud  J. W., Sossi  V., Calne  D. B.
ISSN
0022-3050 (Print)
Statut éditorial
Publié
Date de publication
03/2000
Volume
68
Numéro
3
Pages
313-6
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar
Résumé
OBJECTIVES: To examine the distribution of striatal dopaminergic function in humans with parkinsonism induced by 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP) to determine if there is a caudate-putamen gradient as is seen in idiopathic Parkinson's disease. METHODS: We scanned nine humans exposed to MPTP with parkinsonism ranging from minimal to severe using [(18)F]fluorodopa (FD) and high resolution PET. The results were compared with those of 10 patients with Parkinson's disease and six normal subjects. RESULTS: In the MPTP group there was an equal degree of reduction of dopaminergic function in the caudate and putamen. This was different from the greater putaminal than caudate loss in Parkinson's disease (p<0.001). CONCLUSIONS: Parkinson's disease is not caused by transient exposure to MPTP.
Mots-clé
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*adverse effects Adult Corpus Striatum/*radionuclide imaging Female Humans Male Middle Aged Parkinson Disease, Secondary/etiology/*radionuclide imaging Tomography, Emission-Computed
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 13:49
Dernière modification de la notice
09/05/2019 0:55
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