High-resolution three-dimensional aortic magnetic resonance angiography and quantitative vessel wall characterization of different atherosclerotic stages in a rabbit model

Détails

ID Serval
serval:BIB_C41101933A28
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
High-resolution three-dimensional aortic magnetic resonance angiography and quantitative vessel wall characterization of different atherosclerotic stages in a rabbit model
Périodique
Investigative Radiology
Auteur(s)
Steen H., Lima J.A., Chatterjee S., Kolmakova A., Gao F., Rodriguez E.R., Stuber M.
ISSN
0020-9996
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
42
Numéro
9
Pages
614-621
Langue
anglais
Notes
Evaluation Studies
Résumé
PURPOSE: Atherosclerosis results in a considerable medical and socioeconomic impact on society. We sought to evaluate novel magnetic resonance imaging (MRI) angiography and vessel wall sequences to visualize and quantify different morphologic stages of atherosclerosis in a Watanabe hereditary hyperlipidemic (WHHL) rabbit model. MATERIAL AND METHODS: Aortic 3D steady-state free precession angiography and subrenal aortic 3D black-blood fast spin-echo vessel wall imaging pre- and post-Gadolinium (Gd) was performed in 14 WHHL rabbits (3 normal, 6 high-cholesterol diet, and 5 high-cholesterol diet plus endothelial denudation) on a commercial 1.5 T MR system. Angiographic lumen diameter, vessel wall thickness, signal-/contrast-to-noise analysis, total vessel area, lumen area, and vessel wall area were analyzed semiautomatically. RESULTS: Pre-Gd, both lumen and wall dimensions (total vessel area, lumen area, vessel wall area) of group 2 + 3 were significantly increased when compared with those of group 1 (all P < 0.01). Group 3 animals had significantly thicker vessel walls than groups 1 and 2 (P < 0.01), whereas angiographic lumen diameter was comparable among all groups. Post-Gd, only diseased animals of groups 2 + 3 showed a significant (>100%) signal-to-noise ratio and contrast-to-noise increase. CONCLUSIONS: A combination of novel 3D magnetic resonance angiography and high-resolution 3D vessel wall MRI enabled quantitative characterization of various atherosclerotic stages including positive arterial remodeling and Gd uptake in a WHHL rabbit model using a commercially available 1.5 T MRI system.
Mots-clé
*Algorithms, Animals, Aortic Diseases/*diagnosis, Atherosclerosis/*diagnosis, Image Enhancement/*methods, Image Interpretation, Computer-Assisted/*methods, Imaging, Three-Dimensional/*methods, Magnetic Resonance Angiography/*methods, Male, Rabbits, Reproducibility of Results, Sensitivity and Specificity
Pubmed
Web of science
Création de la notice
02/03/2010 17:04
Dernière modification de la notice
20/08/2019 16:39
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