Evolutionary genomics of nuclear receptors: from twenty-five ancestral genes to derived endocrine systems.

Détails

ID Serval
serval:BIB_C4066A213A2D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Evolutionary genomics of nuclear receptors: from twenty-five ancestral genes to derived endocrine systems.
Périodique
Molecular Biology and Evolution
Auteur(s)
Bertrand S., Brunet F.G., Escriva H., Parmentier G., Laudet V., Robinson-Rechavi M.
ISSN
0737-4038 (Print)
ISSN-L
0737-4038
Statut éditorial
Publié
Date de publication
2004
Volume
21
Numéro
10
Pages
1923-1937
Langue
anglais
Résumé
Bilaterian animals are notably characterized by complex endocrine systems. The receptors for many steroids, retinoids, and other hormones belong to the superfamily of nuclear receptors, which are transcription factors regulating many aspects of development and homeostasis. Despite a diversity of regulatory mechanisms and physiological roles, nuclear receptors share a common protein organization. To obtain the broad picture of bilaterian nuclear hormone receptor evolution, we have characterized the complete set of nuclear receptor genes from nine animal genome sequences and analyzed it in a phylogenetic framework. In addition, expressed sequence tags from key lineages with no available genome sequence were also searched. This allows us to date the evolutionary events that led from an ancestral nuclear receptor gene, in an early metazoan, to present day diversity. We show that there were approximately 25 nuclear receptor genes in Urbilateria, the ancestor of bilaterians, at which point the fundamental diversity of the subfamily was already established. Surprisingly, differential gene loss played an important role in the evolution of different nuclear receptor sets in bilaterian lineages. The nuclear receptor distribution was also shaped by periods of gene duplication, essentially in vertebrates, as well as a lineage-specific duplication burst in nematodes. Our results imply that the genes for major receptors such as steroid receptors or thyroid hormone receptors were present in Urbilateria.
Mots-clé
Animals, Endocrine System, Evolution, Molecular, Genetic Markers, Insects/genetics, Likelihood Functions, Multigene Family, Nematoda/genetics, Phylogeny, Receptors, Cytoplasmic and Nuclear/genetics, Urochordata/genetics, Vertebrates/genetics
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 18:47
Dernière modification de la notice
09/05/2019 0:55
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