Peroxisome Proliferator-Activated Receptor beta/delta in the Brain: Facts and Hypothesis.

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Version: Final published version
Serval ID
serval:BIB_C3FD2A44950A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Peroxisome Proliferator-Activated Receptor beta/delta in the Brain: Facts and Hypothesis.
Journal
PPAR Research
Author(s)
Hall M.G., Quignodon L., Desvergne B.
ISSN
1687-4757[print]
Publication state
Published
Issued date
2008
Volume
2008
Pages
780452
Language
english
Notes
Article ID 780452
Abstract
peroxisome proliferator-activated receptors (PPARs) are nuclear receptors acting as lipid sensors. Besides its metabolic activity in peripheral organs, the PPAR beta/delta isotype is highly expressed in the brain and its deletion in mice induces a brain developmental defect. Nevertheless, exploration of PPARbeta action in the central nervous system remains sketchy. The lipid content alteration observed in PPARbeta null brains and the positive action of PPARbeta agonists on oligodendrocyte differentiation, a process characterized by lipid accumulation, suggest that PPARbeta acts on the fatty acids and/or cholesterol metabolisms in the brain. PPARbeta could also regulate central inflammation and antioxidant mechanisms in the damaged brain. Even if not fully understood, the neuroprotective effect of PPARbeta agonists highlights their potential benefit to treat various acute or chronic neurological disorders. In this perspective, we need to better understand the basic function of PPARbeta in the brain. This review proposes different leads for future researches.
Pubmed
Open Access
Yes
Create date
06/04/2009 15:56
Last modification date
20/08/2019 15:39
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