Peroxisome Proliferator-Activated Receptor beta/delta in the Brain: Facts and Hypothesis.

Détails

Ressource 1Télécharger: BIB_C3FD2A44950A.P001.pdf (1907.97 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_C3FD2A44950A
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Peroxisome Proliferator-Activated Receptor beta/delta in the Brain: Facts and Hypothesis.
Périodique
PPAR Research
Auteur(s)
Hall M.G., Quignodon L., Desvergne B.
ISSN
1687-4757[print]
Statut éditorial
Publié
Date de publication
2008
Volume
2008
Pages
780452
Langue
anglais
Notes
Article ID 780452
Résumé
peroxisome proliferator-activated receptors (PPARs) are nuclear receptors acting as lipid sensors. Besides its metabolic activity in peripheral organs, the PPAR beta/delta isotype is highly expressed in the brain and its deletion in mice induces a brain developmental defect. Nevertheless, exploration of PPARbeta action in the central nervous system remains sketchy. The lipid content alteration observed in PPARbeta null brains and the positive action of PPARbeta agonists on oligodendrocyte differentiation, a process characterized by lipid accumulation, suggest that PPARbeta acts on the fatty acids and/or cholesterol metabolisms in the brain. PPARbeta could also regulate central inflammation and antioxidant mechanisms in the damaged brain. Even if not fully understood, the neuroprotective effect of PPARbeta agonists highlights their potential benefit to treat various acute or chronic neurological disorders. In this perspective, we need to better understand the basic function of PPARbeta in the brain. This review proposes different leads for future researches.
Pubmed
Open Access
Oui
Création de la notice
06/04/2009 16:56
Dernière modification de la notice
09/05/2019 0:55
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