Quantitative Analysis of Myelin and Axonal Remodeling in the Uninjured Motor Network After Stroke.

Détails

ID Serval
serval:BIB_C3C6BA2AD1B6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Quantitative Analysis of Myelin and Axonal Remodeling in the Uninjured Motor Network After Stroke.
Périodique
Brain Connectivity
Auteur(s)
Lin Y.C., Daducci A., Meskaldji D.E., Thiran J.P., Michel P., Meuli R., Krueger G., Menegaz G., Granziera C.
ISSN
2158-0022 (Electronic)
ISSN-L
2158-0014
Statut éditorial
Publié
Date de publication
09/2015
Peer-reviewed
Oui
Volume
5
Numéro
7
Pages
401-412
Langue
anglais
Résumé
Contralesional brain connectivity plasticity was previously reported after stroke. This study aims at disentangling the biological mechanisms underlying connectivity plasticity in the uninjured motor network after an ischemic lesion. In particular, we measured generalized fractional anisotropy (GFA) and magnetization transfer ratio (MTR) to assess whether poststroke connectivity remodeling depends on axonal and/or myelin changes. Diffusion-spectrum imaging and magnetization transfer MRI at 3T were performed in 10 patients in acute phase, at 1 and 6 months after stroke, which was affecting motor cortical and/or subcortical areas. Ten age- and gender-matched healthy volunteers were scanned 1 month apart for longitudinal comparison. Clinical assessment was also performed in patients prior to magnetic resonance imaging (MRI). In the contralesional hemisphere, average measures and tract-based quantitative analysis of GFA and MTR were performed to assess axonal integrity and myelination along motor connections as well as their variations in time. Mean and tract-based measures of MTR and GFA showed significant changes in a number of contralesional motor connections, confirming both axonal and myelin plasticity in our cohort of patients. Moreover, density-derived features (peak height, standard deviation, and skewness) of GFA and MTR along the tracts showed additional correlation with clinical scores than mean values. These findings reveal the interplay between contralateral myelin and axonal remodeling after stroke.
Mots-clé
Adult, Aged, Aged, 80 and over, Anisotropy, Axons/pathology, Brain/pathology, Diffusion Magnetic Resonance Imaging, Female, Humans, Male, Middle Aged, Motor Neurons/pathology, Myelin Sheath/pathology, Nerve Net/pathology, Pyramidal Tracts/pathology, Stroke/pathology
Pubmed
Création de la notice
15/10/2014 13:11
Dernière modification de la notice
03/03/2018 21:12
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