Impaired antibody response causes persistence of prototypic T cell-contained virus.

Détails

ID Serval
serval:BIB_C3BFCB6EFACA
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Impaired antibody response causes persistence of prototypic T cell-contained virus.
Périodique
Plos Biology
Auteur(s)
Bergthaler A., Flatz L., Verschoor A., Hegazy A.N., Holdener M., Fink K., Eschli B., Merkler D., Sommerstein R., Horvath E., Fernandez M., Fitsche A., Senn B.M., Verbeek J.S., Odermatt B., Siegrist C.A., Pinschewer D.D.
ISSN
1545-7885 (Electronic)
ISSN-L
1544-9173
Statut éditorial
Publié
Date de publication
2009
Volume
7
Numéro
4
Pages
e1000080
Langue
anglais
Résumé
CD8 T cells are recognized key players in control of persistent virus infections, but increasing evidence suggests that assistance from other immune mediators is also needed. Here, we investigated whether specific antibody responses contribute to control of lymphocytic choriomeningitis virus (LCMV), a prototypic mouse model of systemic persistent infection. Mice expressing transgenic B cell receptors of LCMV-unrelated specificity, and mice unable to produce soluble immunoglobulin M (IgM) exhibited protracted viremia or failed to resolve LCMV. Virus control depended on immunoglobulin class switch, but neither on complement cascades nor on Fc receptor gamma chain or Fc gamma receptor IIB. Cessation of viremia concurred with the emergence of viral envelope-specific antibodies, rather than with neutralizing serum activity, and even early nonneutralizing IgM impeded viral persistence. This important role for virus-specific antibodies may be similarly underappreciated in other primarily T cell-controlled infections such as HIV and hepatitis C virus, and we suggest this contribution of antibodies be given consideration in future strategies for vaccination and immunotherapy.
Mots-clé
Animals, Antibodies, Viral/physiology, Arenaviridae Infections/immunology, CD8-Positive T-Lymphocytes/physiology, Complement System Proteins/immunology, Disease Models, Animal, Immunoglobulin Class Switching/physiology, Immunoglobulin G/immunology, Immunoglobulin M/immunology, Lymphocytic choriomeningitis virus/immunology, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Receptors, Antigen, B-Cell, Viral Load, Viremia/immunology, Virus Diseases/immunology
Pubmed
Web of science
Open Access
Oui
Création de la notice
23/03/2012 19:30
Dernière modification de la notice
09/05/2019 0:54
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