Article: article from journal or magazin.
Bystander activation of CD4+ T cells.
European Journal of Immunology
Publication types: Comment ; Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Bystander activation of T cells, i.e. the stimulation of unrelated (heterologous) T cells by cytokines during an Ag-specific T-cell response, has been best described for CD8(+) T cells. In the CD8(+) compartment, the release of IFN and IFN-inducers leads to the production of IL-15, which mediates the proliferation of CD8(+) T cells, notably memory-phenotype CD8(+) T cells. CD4(+) T cells also undergo bystander activation, however, the signals inducing this Ag-nonspecific stimulation of CD4(+) T cells are less well known. A study in this issue of the European Journal of Immunology sheds light on this aspect, suggesting that common gamma-chain cytokines including IL-2 might be involved in bystander activation of CD4(+) T cells.
Adoptive Transfer, Animals, Bystander Effect/immunology, CD4-Positive T-Lymphocytes/immunology, Humans, Immunologic Memory, Interleukin Receptor Common gamma Subunit/immunology, Interleukin-15/pharmacology, Interleukin-2/biosynthesis, Interleukin-2/pharmacology, Interleukin-2 Receptor alpha Subunit/immunology, Interleukin-2 Receptor beta Subunit/immunology, Interleukins/immunology, Lymphocyte Activation, Mice, Mice, Transgenic, Models, Immunological, Signal Transduction/immunology, Tetanus Toxoid/immunology
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