Epigenetic switch controls social actions.

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Serval ID
serval:BIB_C36824F58E0E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
UNIL/CHUV
Title
Epigenetic switch controls social actions.
Journal
Neuron
Author(s)
Pedini G., Bagni C.
ISSN
1097-4199 (Electronic)
ISSN-L
0896-6273
Publication state
Published
Issued date
06/04/2022
Peer-reviewed
Oui
Volume
110
Number
7
Pages
1085-1087
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Mutations in epigenetic factors are associated with autism spectrum disorder (ASD). In this issue of Neuron, Yan et al. (2022) show that the antagonism of ASH1L and PRC2 switches the equilibrium of histone methylation at the ephrin receptor A7 locus, causing decreased EphA7 expression, deficits in synaptic pruning, and ASD-like behaviors.
Keywords
Autism Spectrum Disorder/genetics, Autism Spectrum Disorder/metabolism, Epigenesis, Genetic, Epigenomics, Humans, Mutation/genetics
OAI-PMH
oai:serval.unil.ch:BIB_C36824F58E0E
DOI
10.1016/j.neuron.2022.03.028
Pubmed
35390284
Create date
25/04/2022 13:14
Last modification date
04/10/2022 6:38
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