Lungscape: resected non-small-cell lung cancer outcome by clinical and pathological parameters.

Details

Serval ID
serval:BIB_C367F4947944
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Lungscape: resected non-small-cell lung cancer outcome by clinical and pathological parameters.
Journal
Journal of thoracic oncology
Author(s)
Peters S., Weder W., Dafni U., Kerr K.M., Bubendorf L., Meldgaard P., O'Byrne K.J., Wrona A., Vansteenkiste J., Felip E., Marchetti A., Savic S., Lu S., Smit E., Dingemans A.M., Blackhall F.H., Baas P., Camps C., Rosell R., Stahel R.A.
Working group(s)
ETOP Lungscape Investigators
Contributor(s)
Stahel R.A., Rosell R., Blackhall F., Dafni U., Kerr K.M., Taron M., Molina M.Á., Bubendorf L., Weder W., Thunnissen E., Peters S., Hiltbrunner A., Kammler R., Marbot M., Maibach R., Ruepp B., Dafni U., Kassapian M., Polydoropoulou V., Poulopoulou S., Meldgaard P., Hager H., Højsgaard A., Weder W., Soltermann A., Tischler V., Storz M., Vrugt B., Friess M., Curioni A., O'Byrne K., Finn S., McGovern E., Young V., Gray S., Enright C., Gately K., Walker J., Barr M., Vansteenkiste J., Verbeken E., Nackaerts K., Dooms C., Oyen C., Peeters L., Lepers S., Vliegen L., Roskams T., Van Der Borght S., Vandenberghe P., Dziadziuszko R., Biernat W., Sejda A., Rzyman W., Jassem J., Maciejewska-Izdebska A., Felip E., Hernandez-Losa J., Sansano I., Canela M., Garrell N.M., Marchetti A., Malatesta S., Mucilli F., Irtelli L., Buttitta F., Bubendorf L., Savic S., Lardinois D., Zippelius A., Kerr K.M., Nicolson M., Remmen H., Stevenson D.A., Price N., Lu S., Jie Z., Tan Q., Cheng Z., Thunnissen E., Smit E., van Setten C., Dingemans A.M., Speel E.J., Maessen J., Bendek M., Adjei A.A., Cheney R., Pine M.B., Reid M., Morrison C., Taylor E., Blackhall F., Nonaka D., Harris J., Wallace A., Shah R., Summers Y., Quinn A.M., Booton R., Baas P., de Jong J., Klomp H., Mahn M., Obbink M.G., Rosenberg E.H., Nederlof P., Camps C., Jantus-Lewintre E.
ISSN
1556-1380 (Electronic)
ISSN-L
1556-0864
Publication state
Published
Issued date
11/2014
Peer-reviewed
Oui
Volume
9
Number
11
Pages
1675-1684
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The Lungscape project was designed to address the impact of clinical, pathological, and molecular characteristics on outcome in resected non-small- cell lung cancer (NSCLC).
A decentralized biobank with fully annotated tissue samples was established. Selection criteria for participating centers included sufficient number of cases, tissue microarray building capability, and documented ethical approval. Patient selection was based on availability of comprehensive clinical data, radical resection between 2003 and 2009 with adequate follow-up, and adequate quantity and quality of formalin-fixed tissue.
Fifteen centers contributed 2449 cases. The 5-year overall survival (OS) was 69.6% and 63.6% for stages IA and IB, 51.6% and 47.7% for stages IIA and IIB, and 29.0% and 13.0% for stages IIIA and IIIB, respectively (p < 0.001). Median and 5-year relapse-free survival (RFS) were 52.8 months and 47.3%, respectively. Distant relapse was recorded for 44.4%, local for 26.0%, and both for 16.9% of patients. Based on multivariate analysis for the OS, RFS, and time to relapse, the factors significantly associated with all of them are performance status and pathological stage.
The aim of this report is to present the results from Lungscape, the first large series reporting on NSCLC surgical outcome measured not only by OS but also by RFS and time to relapse and including multivariate analysis by significant clinical and pathological prognostic parameters. As tissue from all patients is preserved locally and is available for detailed molecular investigations, Lungscape provides an excellent basis to evaluate the influence of molecular parameters on the disease outcome after radical resection, besides providing an overview of the molecular landscape of stage I to III NSCLC.

Keywords
Adult, Aged, Aged, 80 and over, Carcinoma, Non-Small-Cell Lung/pathology, Carcinoma, Non-Small-Cell Lung/surgery, Female, Humans, Lung Neoplasms/pathology, Lung Neoplasms/surgery, Male, Middle Aged, Treatment Outcome, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
16/01/2018 13:41
Last modification date
20/08/2019 15:38
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