Impact of vesicoureteral reflux on the size of renal lesions after an episode of acute pyelonephritis

Détails

ID Serval
serval:BIB_C34DB142522E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Impact of vesicoureteral reflux on the size of renal lesions after an episode of acute pyelonephritis
Périodique
Journal of Urology
Auteur(s)
Gonzalez  E., Papazyan  J. P., Girardin  E.
ISSN
0022-5347
Statut éditorial
Publié
Date de publication
02/2005
Peer-reviewed
Oui
Volume
173
Numéro
2
Pages
571-4; discussion 574-5
Notes
Journal Article --- Old month value: Feb
Résumé
PURPOSE: We determined the impact of vesicoureteral reflux (VUR) on the size of renal lesions in children after an episode of acute pyelonephritis. MATERIALS AND METHODS: A total of 161 children (mean age 2.44 years) with acute pyelonephritis were studied. All had renal lesions on dimercapto-succinic acid scintigraphy done at admission to the hospital. A second dimercapto-succinic acid scan was performed at 3 months. Voiding cystourethrography was done at 6 weeks and VUR was graded I to V. For each renal unit layouts of renal lesions were drawn, and the damage surface was calculated and reported for the total surface of the kidney. RESULTS: Mean size of acute lesions and scars increased with severity of reflux (p <0.0001), with an important overlap of individual values. Mean size of renal scars in the group of renal units with acute lesions was 5.8% +/- 8.5% in patients without VUR, 9.9% +/- 7.3% in those with grade I reflux, 7.7% +/- 11.0% in those with grade II reflux, 17.7% +/- 14.7% in those with grade III reflux and 17.4% +/- 27.7% in those with grade IV reflux (p <0.001). The size of renal lesions decreased significantly with time. The rate of regression of lesions decreased with increasing reflux. When analyzed according to 3 age groups sizes of scars increased significantly with age. CONCLUSIONS: VUR has an impact on the size of renal lesions after an episode of pyelonephritis. Children with a grade III or IV reflux are more likely to have larger renal scars. On the other hand, acute lesions of important size may develop even in the absence of VUR.
Mots-clé
Acute Disease Child Child, Preschool Cicatrix/*etiology/*pathology/radionuclide imaging Female Humans Infant Infant, Newborn Kidney Diseases/*etiology/*pathology/radionuclide imaging Male Pyelonephritis/*complications Vesico-Ureteral Reflux/*complications
Pubmed
Web of science
Création de la notice
15/01/2008 15:27
Dernière modification de la notice
03/03/2018 21:11
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