Cyclophosphamide treatment regulates the balance of functional/exhausted tumor-specific CD8(+) T cells.

Détails

ID Serval
serval:BIB_C347ED090FBF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Cyclophosphamide treatment regulates the balance of functional/exhausted tumor-specific CD8(+) T cells.
Périodique
Oncoimmunology
Auteur(s)
Hanoteau A., Henin C., Svec D., Bisilliat Donnet C., Denanglaire S., Colau D., Romero P., Leo O., Van den Eynde B., Moser M.
ISSN
2162-4011 (Print)
ISSN-L
2162-4011
Statut éditorial
Publié
Date de publication
2017
Peer-reviewed
Oui
Volume
6
Numéro
8
Pages
e1318234
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
An important question is how chemotherapy may (re-)activate tumor-specific immunity. In this study, we provide a phenotypic, functional and genomic analysis of tumor-specific CD8(+) T cells in tumor (P815)-bearing mice, treated or not with cyclophosphamide. Our data show that chemotherapy favors the development of effector-type lymphocytes in tumor bed, characterized by higher KLRG-1 expression, lower PD-1 expression and increased cytotoxicity. This suggests re-engagement of T lymphocytes into the effector program. IFN-I appears involved in this remodeling. Our findings provide some insight into how cyclophosphamide regulates the amplitude and quality of tumor-specific immune responses.

Mots-clé
CD8+ T cells, cyclophosphamide, effector function, exhaustion, tumor-specific immunity
Pubmed
Web of science
Création de la notice
25/09/2017 18:42
Dernière modification de la notice
03/03/2018 21:11
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