Choroidal arteriovenous anastomoses: a hypothesis for the pathogenesis of central serous chorioretinopathy and other pachychoroid disease spectrum abnormalities.

Details

Ressource 1Download: 35179828_BIB_C32D46ADC2BD.pdf (2816.14 [Ko])
State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_C32D46ADC2BD
Type
Article: article from journal or magazin.
Publication sub-type
Editorial
Collection
Publications
Institution
Title
Choroidal arteriovenous anastomoses: a hypothesis for the pathogenesis of central serous chorioretinopathy and other pachychoroid disease spectrum abnormalities.
Journal
Acta ophthalmologica
Author(s)
Brinks J., van Dijk EHC, Meijer O.C., Schlingemann R.O., Boon CJF
ISSN
1755-3768 (Electronic)
ISSN-L
1755-375X
Publication state
Published
Issued date
12/2022
Peer-reviewed
Oui
Volume
100
Number
8
Pages
946-959
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The pachychoroid disease spectrum (PDS) includes several chorioretinal diseases that share specific choroidal abnormalities. Although their pathophysiological basis is poorly understood, diseases that are part of the PDS have been hypothesized to be the result of venous congestion. Within the PDS, central serous chorioretinopathy is the most common condition associated with vision loss, due to an accumulation of subretinal fluid in the macula. Central serous chorioretinopathy is characterized by distinct risk factors, most notably a high prevalence in males and exposure to corticosteroids. Interestingly, sex differences and corticosteroids are also strongly associated with specific types of arteriovenous anastomoses in the human body, including dural arteriovenous fistula and surgically created arteriovenous shunts. In this manuscript, we assess the potential of such arteriovenous anastomoses in the choroid as a causal mechanism of the PDS. We propose how this may provide a novel unifying concept on the pathophysiological basis of the PDS, and present cases in which this mechanism may play a role.
Keywords
Female, Humans, Male, Central Serous Chorioretinopathy/diagnosis, Central Serous Chorioretinopathy/etiology, Fluorescein Angiography, Arteriovenous Anastomosis, Tomography, Optical Coherence, Choroid/pathology, Choroid Diseases/diagnosis, Choroid Diseases/etiology, arteriovenous anastomoses, arteriovenous fistula, corticosteroids, pachychoroid disease spectrum, sex differences, venous congestion
Pubmed
Web of science
Open Access
Yes
Create date
28/02/2022 11:57
Last modification date
25/01/2024 8:44
Usage data