Drug-induced tendinopathy: From physiology to clinical applications.

Details

Serval ID
serval:BIB_C32A9D81164F
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Drug-induced tendinopathy: From physiology to clinical applications.
Journal
Joint, Bone, Spine : Revue du Rhumatisme
Author(s)
Kirchgesner T., Larbi A., Omoumi P., Malghem J., Zamali N., Manelfe J., Lecouvet F., Vande Berg B., Djebbar S., Dallaudière B.
ISSN
1778-7254 (Electronic)
ISSN-L
1297-319X
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
81
Number
6
Pages
485-492
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish, pdf : Review
Abstract
Drug-induced tendon toxicity is rare but often underestimated. To date, four main drug classes have been incriminated in tendinopathies. Quinolones and long-term glucocorticoids are the most widely known, but statins and aromatase inhibitors can also induce tendon damage. The specific pathophysiological mechanisms responsible for drug-induced tendinopathies remain unknown. Proven risk factors have been identified, such as age older than 60years, pre-existing tendinopathy, and potentiation of toxic effects when several drug classes are used in combination. Mean time to symptom onset varies from a few days with quinolones to several months with statins and several years for long-term glucocorticoid therapy. The most common sites of involvement are the lower limb tendons, most notably the body of the Achilles tendon. The first part of this review discusses tendon anatomy and the pathophysiology and radiological manifestations of tendinopathies. The second part provides details on the main characteristics of each of the drugs classes associated with tendon toxicity.
Pubmed
Create date
06/10/2014 16:27
Last modification date
20/08/2019 15:38
Usage data