IL-6 protein production by airway epithelial(-like) cells disabled in IL-6 mRNA degradation

Détails

ID Serval
serval:BIB_C2F497F455D7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
IL-6 protein production by airway epithelial(-like) cells disabled in IL-6 mRNA degradation
Périodique
Cytokine
Auteur(s)
Lutter  R., Loman  S., Snoek  M., Roger  T., Out  T. A., Jansen  H. M.
ISSN
1043-4666 (Print)
Statut éditorial
Publié
Date de publication
08/2000
Volume
12
Numéro
8
Pages
1275-9
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug
Résumé
IL-6 mRNA and protein expression in human airway epithelial-like H292 cells depends on rapid, but regulable IL-6 mRNA degradation. We restricted IL-6 mRNA degradation by partially inhibiting protein synthesis and studied the IL-6 response. Despite partial inhibition of protein synthesis, IL-6 protein production was increased and prolonged. Furthermore, the threshold concentration for stimuli of IL-6 protein production decreased and the dose-response curves became steeper. Similar findings were obtained with primary human bronchial epithelial cells. This exaggerated production may apply to other proteins encoded by labile mRNA and is likely to occur during viral infection of airway epithelial cells.
Mots-clé
Cells, Cultured Cycloheximide/*pharmacology Epithelial Cells/drug effects/metabolism Humans Interleukin-6/*biosynthesis/genetics RNA, Messenger/drug effects/metabolism
Pubmed
Web of science
Création de la notice
25/01/2008 14:35
Dernière modification de la notice
03/03/2018 21:10
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