Influence of magnetic field strength and image registration strategy on voxel-based morphometry in a study of Alzheimer's disease.

Détails

ID Serval
serval:BIB_C27FE9DAE9FE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Influence of magnetic field strength and image registration strategy on voxel-based morphometry in a study of Alzheimer's disease.
Périodique
Human Brain Mapping
Auteur(s)
Marchewka A., Kherif F., Krueger G., Grabowska A., Frackowiak R., Draganski B.
Collaborateur(s)
Alzheimer's Disease Neuroimaging Initiative
ISSN
1097-0193 (Electronic)
ISSN-L
1065-9471
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
35
Numéro
5
Pages
1865-1874
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Multi-centre data repositories like the Alzheimer's Disease Neuroimaging Initiative (ADNI) offer a unique research platform, but pose questions concerning comparability of results when using a range of imaging protocols and data processing algorithms. The variability is mainly due to the non-quantitative character of the widely used structural T1-weighted magnetic resonance (MR) images. Although the stability of the main effect of Alzheimer's disease (AD) on brain structure across platforms and field strength has been addressed in previous studies using multi-site MR images, there are only sparse empirically-based recommendations for processing and analysis of pooled multi-centre structural MR data acquired at different magnetic field strengths (MFS). Aiming to minimise potential systematic bias when using ADNI data we investigate the specific contributions of spatial registration strategies and the impact of MFS on voxel-based morphometry in AD. We perform a whole-brain analysis within the framework of Statistical Parametric Mapping, testing for main effects of various diffeomorphic spatial registration strategies, of MFS and their interaction with disease status. Beyond the confirmation of medial temporal lobe volume loss in AD, we detect a significant impact of spatial registration strategy on estimation of AD related atrophy. Additionally, we report a significant effect of MFS on the assessment of brain anatomy (i) in the cerebellum, (ii) the precentral gyrus and (iii) the thalamus bilaterally, showing no interaction with the disease status. We provide empirical evidence in support of pooling data in multi-centre VBM studies irrespective of disease status or MFS.
Pubmed
Web of science
Création de la notice
05/06/2013 12:40
Dernière modification de la notice
03/03/2018 21:10
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