Quantification of tremor and bradykinesia in Parkinson's disease using a novel ambulatory monitoring system.

Détails

ID Serval
serval:BIB_C22C1AEAC517
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Quantification of tremor and bradykinesia in Parkinson's disease using a novel ambulatory monitoring system.
Périodique
Ieee Transactions on Bio-medical Engineering
Auteur(s)
Salarian A., Russmann H., Wider C., Burkhard P.R., Vingerhoets F.J., Aminian K.
ISSN
0018-9294[print], 0018-9294[linking]
Statut éditorial
Publié
Date de publication
02/2007
Volume
54
Numéro
2
Pages
313-322
Langue
anglais
Notes
Journal Article Research Support, Non-U.S. Gov't --- Old month value: Feb
Résumé
An ambulatory system for quantification of tremor and bradykinesia in patients with Parkinson's disease (PD) is presented. To record movements of the upper extremities, a sensing units which included miniature gyroscopes, has been fixed to each of the forearms. An algorithm to detect and quantify tremor and another algorithm to quantify bradykinesia have been proposed and validated. Two clinical studies have been performed. In the first study, 10 PD patients and 10 control subjects participated in a 45-min protocol of 17 typical daily activities. The algorithm for tremor detection showed an overall sensitivity of 99.5% and a specificity of 94.2% in comparison to a video reference. The estimated tremor amplitude showed a high correlation to the Unified Parkinson's Disease Rating Scale (UPDRS) tremor subscore (e.g., r = 0.87, p < 0.001 for the roll axis). There was a high and significant correlation between the estimated bradykinesia related parameters estimated for the whole period of measurement and respective UPDRS subscore (e.g., r = -0.83, p < 0.001 for the roll axis). In the second study, movements of upper extremities of 11 PD patients were recorded for periods of 3-5 hr. The patients were moving freely during the measurements. The effects of selection of window size used to calculate tremor and bradykinesia related parameters on the correlation between UPDRS and these parameters were studied. By selecting a window similar to the period of the first study, similar correlations were obtained. Moreover, one of the bradykinesia related parameters showed significant correlation (r = -0.74, p < 0.01) to UPDRS with window sizes as short as 5 min. Our study provides evidence that objective, accurate and simultaneous assessment of tremor and bradykinesia can be achieved in free moving PD patients during their daily activities.
Mots-clé
Aged, Diagnosis, Computer-Assisted/instrumentation, Diagnosis, Computer-Assisted/methods, Equipment Design, Equipment Failure Analysis, Female, Humans, Hypokinesia/diagnosis, Hypokinesia/etiology, Male, Middle Aged, Monitoring, Ambulatory/instrumentation, Monitoring, Ambulatory/methods, Parkinson Disease/complications, Parkinson Disease/diagnosis, Pattern Recognition, Automated/methods, Reproducibility of Results, Sensitivity and Specificity
Pubmed
Web of science
Création de la notice
25/01/2008 13:49
Dernière modification de la notice
03/03/2018 21:09
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