Association between obesity and glomerular hyperfiltration: the confounding effect of smoking and sodium and protein intakes.

Détails

ID Serval
serval:BIB_C229DE25A98E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Association between obesity and glomerular hyperfiltration: the confounding effect of smoking and sodium and protein intakes.
Périodique
European journal of nutrition
Auteur(s)
Ogna A., Forni Ogna V., Bochud M., Guessous I., Paccaud F., Burnier M., Wuerzner G.
ISSN
1436-6215 (Electronic)
ISSN-L
1436-6207
Statut éditorial
Publié
Date de publication
04/2016
Peer-reviewed
Oui
Volume
55
Numéro
3
Pages
1089-1097
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Glomerular hyperfiltration has been suggested as a possible mechanism linking obesity and chronic kidney disease (CKD), independently of classical risk factors. We explored the association of overweight and obesity with glomerular hyperfiltration in a large sample of the Swiss adult population, accounting for several confounders including dietary factors.
Data from a 2010 to 2012 cross-sectional population-based survey in Switzerland were used. Creatinine clearance (CrCl) was determined from 24-h urine collection; CrCl > 140 ml/min was used to define glomerular hyperfiltration. Participants were categorized into lean (<25 kg/m(2)), overweight (25-29.9 kg/m(2)) and obese (≥30 kg/m(2)) according to body mass index (BMI).
A total of 1339 participants were included in the analysis [median (IQR) age 49.4 (34.3-63.5) years, 48.9 % men]. The prevalences of overweight and obesity were 32.2 and 14.2 %, respectively. Median CrCl was 102[84-121] ml/min in lean, 110 [87-136] ml/min in overweight and 124 [97-150] ml/min in obese participants (p < 0.001). The prevalence of glomerular hyperfiltration increased across BMI categories (10.4, 20.8 and 34.7 %, respectively; p < 0.001). This positive association remained significant after adjusting for age, sex, hypertension, diabetes, smoking and dietary factors (sodium and protein intakes): odds ratio [95 %CI] 2.39 [1.52-3.76] (p < 0.001) for overweight versus lean and 4.10[2.31-7.27] (p < 0.001) for obesity versus lean.
BMI categories and glomerular hyperfiltration are positively associated, independently of other known CKD risk factors and dietary confounders, suggesting that glomerular hyperfiltration may represent an early renal phenotype in obesity. Our observations confirm the significant association of glomerular hyperfiltration with sodium and protein intakes and identify sodium intake as an important modifying factor of the association between hyperfiltration and obesity.

Mots-clé
Adult, Body Mass Index, Creatinine/urine, Cross-Sectional Studies, Dietary Proteins/administration & dosage, Dietary Proteins/adverse effects, Female, Glomerular Filtration Rate, Humans, Kidney/physiopathology, Kidney Diseases/complications, Kidney Diseases/epidemiology, Kidney Diseases/urine, Male, Middle Aged, Obesity/complications, Obesity/epidemiology, Obesity/urine, Overweight/complications, Overweight/epidemiology, Overweight/urine, Prevalence, Risk Factors, Smoking/adverse effects, Sodium, Dietary/administration & dosage, Sodium, Dietary/adverse effects, Switzerland
Pubmed
Création de la notice
11/08/2015 9:35
Dernière modification de la notice
03/03/2018 21:09
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