In vivo assessment of myelination by phase imaging at high magnetic field.

Détails

ID Serval
serval:BIB_C21C9C794DE6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
In vivo assessment of myelination by phase imaging at high magnetic field.
Périodique
Neuroimage
Auteur(s)
Lodygensky G.A., Marques J.P., Maddage R., Perroud E., Sizonenko S.V., Hüppi P.S., Gruetter R.
ISSN
1095-9572 (Electronic)
ISSN-L
1053-8119
Statut éditorial
Publié
Date de publication
2012
Volume
59
Numéro
3
Pages
1979-1987
Langue
anglais
Résumé
The present study evaluated the potential of using the phase of T2* weighted MR images to characterize myelination during brain development and pathology in rodents at 9.4 T. Phase contrast correlated with myelin content assessed by histology and suggests that most contrast between white and cortical gray matter is modulated by myelin. Ex vivo experiments showed that gray-white matter phase contrast remains unchanged after iron extraction. In dysmyelinated shiverer mice, phase imaging correlated strongly with myelin staining, showing reduced contrast between white and gray matter when compared to healthy controls. We conclude that high-resolution phase images, acquired at high field, allow assessment of myelination and dysmyelination.
Pubmed
Web of science
Création de la notice
02/03/2012 15:55
Dernière modification de la notice
03/03/2018 21:09
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