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Biodistribution of anti-CEA F(ab')2 fragments after intra-arterial and intravenous injection in patients with liver metastases due to colorectal carcinoma.
Nuclear Medicine Communications
The biodistribution of simultaneous intra-arterial and intravenous injections of a radiolabelled anti-CEA MAb F(ab')2 fragment was studied in three patients with liver metastases from colorectal cancer. Identical MAb fragments, labelled with either 125I or 131I, were injected over a period of 30 min into the hepatic artery and into a peripheral vein. After 1 or 2 days, biodistribution was measured in the surgically removed metastases, normal tissue samples and blood. By tissue radioactivity counting, tumour uptake in the range 6.3-9.1% of injected dose per gram was found. Superimposable metastasis-to-blood and metastasis-to-normal liver ratios were obtained for both iodine isotopes in all three patients. The results indicate that the intra-arterial injection of MAb F(ab')2 fragments gives no measurable advantage over more convenient injections into a peripheral vein.
Antibodies, Monoclonal, Carcinoembryonic Antigen/immunology, Colonic Neoplasms/pathology, Colonic Neoplasms/radionuclide imaging, Female, Humans, Immunoglobulin Fab Fragments, Injections, Intra-Arterial, Injections, Intravenous, Iodine Radioisotopes/administration & dosage, Iodine Radioisotopes/diagnostic use, Liver Neoplasms/pathology, Liver Neoplasms/radionuclide imaging, Male, Middle Aged, Radioimmunodetection, Rectal Neoplasms/pathology, Rectal Neoplasms/radionuclide imaging, Sensitivity and Specificity, Tissue Distribution
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