Biodistribution of anti-CEA F(ab')2 fragments after intra-arterial and intravenous injection in patients with liver metastases due to colorectal carcinoma.

Détails

ID Serval
serval:BIB_C20F0160C375
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Biodistribution of anti-CEA F(ab')2 fragments after intra-arterial and intravenous injection in patients with liver metastases due to colorectal carcinoma.
Périodique
Nuclear Medicine Communications
Auteur(s)
Buchegger F., Gillet M., Doenz F., Vogel C.A., Achtari C., Mach J.P., Delaloye B., Delaloye A.B.
ISSN
0143-3636 (Print)
ISSN-L
0143-3636
Statut éditorial
Publié
Date de publication
1996
Peer-reviewed
Oui
Volume
17
Numéro
6
Pages
500-503
Langue
anglais
Résumé
The biodistribution of simultaneous intra-arterial and intravenous injections of a radiolabelled anti-CEA MAb F(ab')2 fragment was studied in three patients with liver metastases from colorectal cancer. Identical MAb fragments, labelled with either 125I or 131I, were injected over a period of 30 min into the hepatic artery and into a peripheral vein. After 1 or 2 days, biodistribution was measured in the surgically removed metastases, normal tissue samples and blood. By tissue radioactivity counting, tumour uptake in the range 6.3-9.1% of injected dose per gram was found. Superimposable metastasis-to-blood and metastasis-to-normal liver ratios were obtained for both iodine isotopes in all three patients. The results indicate that the intra-arterial injection of MAb F(ab')2 fragments gives no measurable advantage over more convenient injections into a peripheral vein.
Mots-clé
Antibodies, Monoclonal, Carcinoembryonic Antigen/immunology, Colonic Neoplasms/pathology, Colonic Neoplasms/radionuclide imaging, Female, Humans, Immunoglobulin Fab Fragments, Injections, Intra-Arterial, Injections, Intravenous, Iodine Radioisotopes/administration & dosage, Iodine Radioisotopes/diagnostic use, Liver Neoplasms/pathology, Liver Neoplasms/radionuclide imaging, Male, Middle Aged, Radioimmunodetection, Rectal Neoplasms/pathology, Rectal Neoplasms/radionuclide imaging, Sensitivity and Specificity, Tissue Distribution
Pubmed
Web of science
Création de la notice
25/01/2008 12:27
Dernière modification de la notice
03/03/2018 21:09
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