CD44v6 is a marker for systemic spread in cutaneous T-cell lymphomas. A comparative study between nodal and cutaneous lymphomas

Détails

ID Serval
serval:BIB_C20D49AF4D86
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
CD44v6 is a marker for systemic spread in cutaneous T-cell lymphomas. A comparative study between nodal and cutaneous lymphomas
Périodique
Journal of Cutaneous Pathology
Auteur(s)
Dommann  S. N., Ziegler  T., Dommann-Schener  C. C., Meyer  J., Panizzon  R., Burg  G.
ISSN
0303-6987 (Print)
Statut éditorial
Publié
Date de publication
10/1995
Volume
22
Numéro
5
Pages
407-12
Notes
Journal Article --- Old month value: Oct
Résumé
Adhesion molecules are involved in leukocyte recruitment, lymphocyte recirculation, and in several aspects of tumour biology. Recent discoveries of surface proteins on tumour cells involved in tumour metastasis may explain the invasive behaviour, the migration involving reversible adhesive contacts, the release into the circulation and the extravasation of tumour cells. CD44 is a family of glycoproteins involved in cell-cell and cell-matrix interactions. The v6 (variant exon v6) form of CD44 confers a metastatic potential onto some carcinoma cells. In the present study, the expression of CD44v6 on skin biopsies of 10 inflammatory skin diseases, 30 cutaneous lymphomas (CL), 11 reactive lymph nodes, 10 primary nodal non-Hodgkin's lymphomas (NHL) and 5 secondary nodal NHL was investigated immunohistochemically. None of the 10 nodal NHL were CD44v6 positive for the neoplastic B- or T-cells, whereas 11/12 CL with systemic spread showed a distinct CD44v6 expression in the skin. CD44v6 was not expressed on the tumour cells of skin biopsies of patients without systemic spread (18 cases of CL). In conclusion, CD44v6 expression is connected to an aggressive behaviour of CL.
Mots-clé
Adult Aged Aged, 80 and over Antigens, CD44/*analysis/*metabolism Dermatitis/pathology Female Humans Lymph Nodes/chemistry Lymphatic Metastasis Lymphoma, Non-Hodgkin/chemistry Lymphoma, T-Cell/*chemistry Male Middle Aged Neoplasm Invasiveness Sezary Syndrome/chemistry Skin/chemistry Skin Neoplasms/*chemistry Staining and Labeling Tumor Markers, Biological/*analysis
Pubmed
Web of science
Création de la notice
25/01/2008 16:55
Dernière modification de la notice
20/08/2019 15:37
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