Article: article from journal or magazin.
The B lymphocyte adhesion molecule CD22 interacts with leukocyte common antigen CD45RO on T cells and alpha 2-6 sialyltransferase, CD75, on B cells
PT - In Vitro PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, P.H.S
Functional maturation of B lymphocytes correlates with expression of the B lineage-specific cell surface glycoprotein CD22. Two CD22 polypeptides have been characterized and suggested to play a role in B cell-B cell interaction as well as in B cell adhesion to monocytes. In this work we provide evidence that CD22 is directly involved in the cognate interaction between B and T cells. One of the two CD22 polypeptides, CD22 beta, interacts with a specific ligand on a subpopulation of CD4+ T cells. Our results suggest that the T cell ligand of CD22 is CD45RO, an isoform of the leukocyte common antigen class of phosphotyrosine phosphatases associated with the helper T cell phenotype. We further demonstrate that CD22 recognizes a second ligand, CD75, expressed predominantly on activated B cells and shown to be a cell surface alpha 2-6 sialyltransferase
Antibodies,Monoclonal/Antigens,CD/genetics/physiology/Antigens,CD22/Antigens,CD3/Antigens,CD45/Antigens,Differentiation,B-Lymphocyte/Antigens,Differentiation,T-Lymphocyte/B-Lymphocytes/Base Sequence/Cell Adhesion/Cell Adhesion Molecules/Cloning,Molecular/Dna/Epitopes/Histocompatibility Antigens/Humans/Lectins/Ligands/Lymphocyte Activation/Molecular Sequence Data/Oligonucleotides/chemistry/Receptors,Antigen,T-Cell/Recombinant Fusion Proteins/Sialyltransferases/Structure-Activity Relationship/T-Lymphocytes/Tonsil/cytology/Research/Antibodies/Antigens/Proteins
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