Life and Death of Immature Neurons in the Juvenile and Adult Primate Amygdala.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_C1CA3073F14B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Life and Death of Immature Neurons in the Juvenile and Adult Primate Amygdala.
Journal
International journal of molecular sciences
Author(s)
Chareyron L.J., Banta Lavenex P., Amaral D.G., Lavenex P.
ISSN
1422-0067 (Electronic)
ISSN-L
1422-0067
Publication state
Published
Issued date
22/06/2021
Peer-reviewed
Oui
Volume
22
Number
13
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
In recent years, a large population of immature neurons has been documented in the paralaminar nucleus of the primate amygdala. A substantial fraction of these immature neurons differentiate into mature neurons during postnatal development or following selective lesion of the hippocampus. Notwithstanding a growing number of studies on the origin and fate of these immature neurons, fundamental questions about the life and death of these neurons remain. Here, we briefly summarize what is currently known about the immature neurons present in the primate ventral amygdala during development and in adulthood, as well as following selective hippocampal lesions. We provide evidence confirming that the distribution of immature neurons extends to the anterior portions of the entorhinal cortex and layer II of the perirhinal cortex. We also provide novel arguments derived from stereological estimates of the number of mature and immature neurons, which support the view that the migration of immature neurons from the lateral ventricle accompanies neuronal maturation in the primate amygdala at all ages. Finally, we propose and discuss the hypothesis that increased migration and maturation of neurons in the amygdala following hippocampal dysfunction may be linked to behavioral alterations associated with certain neurodevelopmental disorders.
Keywords
Age Factors, Amygdala/cytology, Amygdala/metabolism, Animals, Biomarkers, Cell Count, Cell Death, Cell Differentiation, Cell Survival, Gene Expression, Hippocampus/cytology, Hippocampus/metabolism, Immunohistochemistry, Neurons/cytology, Neurons/metabolism, Primates, Temporal Lobe/cytology, Temporal Lobe/metabolism, Williams syndrome, amygdala, hippocampus, lesion, neuroblast, neurodevelopmental disorders, primate, subventricular zone
Pubmed
Web of science
Open Access
Yes
Create date
30/07/2021 10:09
Last modification date
03/03/2022 7:12
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