Physiology of GLP-1--lessons from glucoincretin receptor knockout mice.

Détails

ID Serval
serval:BIB_C1A1B43E6641
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Physiology of GLP-1--lessons from glucoincretin receptor knockout mice.
Périodique
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme
Auteur(s)
Thorens B.
ISSN
0018-5043
Statut éditorial
Publié
Date de publication
2004
Peer-reviewed
Oui
Volume
36
Numéro
11-12
Pages
766-770
Langue
anglais
Résumé
GLP-1 has both peripheral and central actions, as this hormone is secreted by gut endocrine cells and brainstem neurons projecting into the hypothalamus and other brain regions. GLP-1 has multiple regulatory functions participating in the control of glucose homeostasis, beta-cell proliferation and differentiation, food intake, heart rate and even learning. GLP-1 action depends on binding to a specific G-coupled receptor linked to activation of the adenylyl cyclase pathway. Analysis of mice with inactivation of the GLP-1 receptor gene has provided evidence that absence of GLP-1 action in the mouse, despite this hormone potent physiological effects when administered in vivo, only leads to mild abnormalities in glucose homeostasis without any change in body weight. However, a critical role for this hormone and its receptor was demonstrated in the function of the hepatoportal vein glucose sensor, in contrast to that of the pancreatic beta-cells, although absence of both GLP-1 and GIP receptors leads to a more severe phenotype characterized by a beta-cell-autonomous defect in glucose-stimulated insulin secretion. Together, the studies of these glucoincretin receptor knockout mice provide evidence that these hormones are part of complex regulatory systems where multiple redundant signals are involved.
Mots-clé
Animals, Body Weight, Eating, Glucagon, Glucagon-Like Peptide 1, Heart Rate, Islets of Langerhans, Learning, Liver, Mice, Mice, Knockout, Peptide Fragments, Protein Precursors, Receptors, Glucagon
Pubmed
Web of science
Création de la notice
24/01/2008 14:41
Dernière modification de la notice
03/03/2018 21:08
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