Prevalence of latent toxoplasmosis and serological diagnosis of active infection in HIV-positive patients

Details

Serval ID
serval:BIB_C1A11E4C79C2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Prevalence of latent toxoplasmosis and serological diagnosis of active infection in HIV-positive patients
Journal
European Journal of Clinical Microbiology and Infectious Diseases
Author(s)
Zufferey  J., Sugar  A., Rudaz  P., Bille  J., Glauser  M. P., Chave  J. P.
ISSN
0934-9723
Publication state
Published
Issued date
08/1993
Peer-reviewed
Oui
Volume
12
Number
8
Pages
591-5
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug
Abstract
The seroprevalence of latent Toxoplasma gondii infection was determined in a cohort of 715 HIV-positive patients followed up at an HIV outpatient clinic. Using indirect immunofluorescence and direct agglutination assays for detecting IgG, the prevalence of anti-Toxoplasma gondii antibodies was shown to be 50%. During a four-year period, clinically apparent acute toxoplasmosis occurred in 47 patients (43 with cerebral, 3 with ocular and 1 with bone marrow toxoplasmosis) among the 360 patients positive for anti-Toxoplasma gondii IgG and in one patient (with cerebral toxoplasmosis) among the 355 patients who were serologically negative. A significant rise in IgG levels could be shown during acute toxoplasmosis episodes in only 30% of patients, compared with 3% of patients without active toxoplasmosis. During acute toxoplasmosis, IgM antibodies were detected in only two patients (6%) by an immunosorbent agglutination assay and in one (3%) by an enzymatic immunocapture assay. Specific IgA was detected by a non-enzymatic immunocapture assay in six patients (18%) during acute episodes. The very high predictive value (99.7%) of a negative IgG test remains the best serological parameter for excluding an acute episode of toxoplasmosis in HIV-positive patients.
Keywords
Acute Disease Adult Antibodies, Protozoan/*blood CD4-Positive T-Lymphocytes/*immunology Cell Count Cohort Studies HIV Seropositivity/*complications Humans Immunoglobulin G/*blood Immunoglobulin M/blood Incidence Male Middle Aged Toxoplasmosis/blood/complications/epidemiology/*immunology
Pubmed
Web of science
Create date
11/02/2008 12:40
Last modification date
20/08/2019 15:36
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