Responsiveness of renin secretion: a key mechanism in the maintenance of blood pressure

Détails

ID Serval
serval:BIB_C1899F38B118
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Responsiveness of renin secretion: a key mechanism in the maintenance of blood pressure
Périodique
Journal of Hypertension. Supplement
Auteur(s)
Brunner  H. R., Nussberger  J., Waeber  B.
ISSN
0952-1178 (Print)
Statut éditorial
Publié
Date de publication
10/1986
Volume
4
Numéro
4
Pages
S89-94
Notes
Journal Article
Review --- Old month value: Oct
Résumé
The renin-angiotensin system is known to respond to various stimuli with a marked increase in its activity. This phenomenon is well known in relationship to changes in sodium balance. Thus, the antihypertensive effect of diuretics is often blunted or even abolished by an excessive renin response. Water deprivation and alpha-adrenoceptor blockade also elicit considerable renin responses, which as a result become a predominant factor in blood pressure maintenance. Accordingly, the renin system plays a very important role in blood pressure regulation not just because it is spontaneously activated under steady-state conditions, but even more because of its responsiveness to pharmacological and other stimuli. This may explain the surprising efficacy of angiotensin converting enzyme inhibitors, which block the generation of angiotensin II, and thereby all vascular effects of spontaneously elevated renin levels as well as of any renin response.
Mots-clé
Adrenergic alpha-Antagonists/pharmacology Animals Desoxycorticosterone Diet, Sodium-Restricted Diuretics/administration & dosage Humans Hyperaldosteronism/drug therapy Hypertension, Renovascular/chemically induced/drug therapy/*physiopathology Posture Renin/*secretion Water/administration & dosage
Pubmed
Web of science
Création de la notice
05/03/2008 17:40
Dernière modification de la notice
03/03/2018 21:08
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