Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation.

Détails

ID Serval
serval:BIB_C1645F7F3090
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation.
Périodique
Blood
Auteur(s)
Mancini S.J., Mantei N., Dumortier A., Suter U., MacDonald H.R., Radtke F.
ISSN
0006-4971 (Print)
ISSN-L
0006-4971
Statut éditorial
Publié
Date de publication
2005
Peer-reviewed
Oui
Volume
105
Numéro
6
Pages
2340-2342
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Jagged1-mediated Notch signaling has been suggested to be critically involved in hematopoietic stem cell (HSC) self-renewal. Unexpectedly, we report here that inducible Cre-loxP-mediated inactivation of the Jagged1 gene in bone marrow progenitors and/or bone marrow (BM) stromal cells does not impair HSC self-renewal or differentiation in all blood lineages. Mice with simultaneous inactivation of Jagged1 and Notch1 in the BM compartment survived normally following a 5FU-based in vivo challenge. In addition, Notch1-deficient HSCs were able to reconstitute mice with inactivated Jagged1 in the BM stroma even under competitive conditions. In contrast to earlier reports, these data exclude an essential role for Jagged1-mediated Notch signaling during hematopoiesis.
Mots-clé
Animals, Antimetabolites/administration & dosage, Antimetabolites/toxicity, Bone Marrow/physiology, Calcium-Binding Proteins/deficiency, Calcium-Binding Proteins/metabolism, Cell Differentiation/drug effects, Cell Differentiation/physiology, Cell Proliferation, Fluorouracil/administration & dosage, Fluorouracil/toxicity, Hematopoiesis/drug effects, Hematopoiesis/physiology, Hematopoietic Stem Cells/cytology, Hematopoietic Stem Cells/physiology, Integrases/genetics, Intercellular Signaling Peptides and Proteins, Membrane Proteins/deficiency, Membrane Proteins/metabolism, Mice, Mice, Transgenic, Receptors, Notch/deficiency, Receptors, Notch/metabolism, Signal Transduction/drug effects, Signal Transduction/physiology, Stromal Cells/cytology, Stromal Cells/physiology, Viral Proteins/genetics
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2008 12:39
Dernière modification de la notice
09/05/2019 0:45
Données d'usage