IMPs: an RNA-binding protein family that provides a link between stem cell maintenance in normal development and cancer.

Details

Ressource 1Download: PMID27940961.pdf (555.00 [Ko])
State: Public
Version: Final published version
Serval ID
serval:BIB_C1371CD6ABBA
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
IMPs: an RNA-binding protein family that provides a link between stem cell maintenance in normal development and cancer.
Journal
Genes & development
Author(s)
Degrauwe N., Suvà M.L., Janiszewska M., Riggi N., Stamenkovic I.
ISSN
1549-5477 (Electronic)
ISSN-L
0890-9369
Publication state
Published
Issued date
15/11/2016
Peer-reviewed
Oui
Volume
30
Number
22
Pages
2459-2474
Language
english
Notes
Publication types: Review ; Journal Article
Publication Status: ppublish

Abstract
IMPs, also known as insulin-like growth factor 2 (IGF2) messenger RNA (mRNA)-binding proteins (IGF2BPs), are highly conserved oncofetal RNA-binding proteins (RBPs) that regulate RNA processing at several levels, including localization, translation, and stability. Three mammalian IMP paralogs (IMP1-3) have been identified that are expressed in most organs during embryogenesis, where they are believed to play an important role in cell migration, metabolism, and stem cell renewal. Whereas some IMP2 expression is retained in several adult mouse organs, IMP1 and IMP3 are either absent or expressed at very low levels in most tissues after birth. However, all three paralogs can be re-expressed upon malignant transformation and are found in a broad range of cancer types where their expression often correlates with poor prognosis. IMPs appear to resume their physiological functions in malignant cells, which not only contribute to tumor progression but participate in the establishment and maintenance of tumor cell hierarchies. This review summarizes our current understanding of the functions of IMPs during normal development and focuses on a series of recent observations that have provided new insight into how their physiological functions enable IMPs to play a potentially key role in cancer stem cell maintenance and tumor growth.

Pubmed
Web of science
Open Access
Yes
Create date
14/12/2016 16:21
Last modification date
20/08/2019 15:35
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