The SwissLipids knowledgebase for lipid biology.

Détails

Ressource 1Télécharger: 25943471_BIB_C131A548FC6C.pdf (616.18 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_C131A548FC6C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The SwissLipids knowledgebase for lipid biology.
Périodique
Bioinformatics
Auteur(s)
Aimo L., Liechti R., Hyka-Nouspikel N., Niknejad A., Gleizes A., Götz L., Kuznetsov D., David F.P., van der Goot F.G., Riezman H., Bougueleret L., Xenarios I., Bridge A.
ISSN
1367-4811 (Electronic)
ISSN-L
1367-4803
Statut éditorial
Publié
Date de publication
2015
Volume
31
Numéro
17
Pages
2860-2866
Langue
anglais
Résumé
MOTIVATION: Lipids are a large and diverse group of biological molecules with roles in membrane formation, energy storage and signaling. Cellular lipidomes may contain tens of thousands of structures, a staggering degree of complexity whose significance is not yet fully understood. High-throughput mass spectrometry-based platforms provide a means to study this complexity, but the interpretation of lipidomic data and its integration with prior knowledge of lipid biology suffers from a lack of appropriate tools to manage the data and extract knowledge from it.
RESULTS: To facilitate the description and exploration of lipidomic data and its integration with prior biological knowledge, we have developed a knowledge resource for lipids and their biology-SwissLipids. SwissLipids provides curated knowledge of lipid structures and metabolism which is used to generate an in silico library of feasible lipid structures. These are arranged in a hierarchical classification that links mass spectrometry analytical outputs to all possible lipid structures, metabolic reactions and enzymes. SwissLipids provides a reference namespace for lipidomic data publication, data exploration and hypothesis generation. The current version of SwissLipids includes over 244 000 known and theoretically possible lipid structures, over 800 proteins, and curated links to published knowledge from over 620 peer-reviewed publications. We are continually updating the SwissLipids hierarchy with new lipid categories and new expert curated knowledge.
AVAILABILITY: SwissLipids is freely available at http://www.swisslipids.org/.
CONTACT: alan.bridge@isb-sib.ch
SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
Pubmed
Web of science
Open Access
Oui
Création de la notice
12/05/2015 20:43
Dernière modification de la notice
20/08/2019 15:35
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