Massive copper and selenium losses cause life-threatening deficiencies during prolonged continuous renal replacement.

Details

Serval ID
serval:BIB_C114CC9185B1
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Massive copper and selenium losses cause life-threatening deficiencies during prolonged continuous renal replacement.
Journal
Nutrition (Burbank, Los Angeles County, Calif.)
Author(s)
Ben-Hamouda N., Charrière M., Voirol P., Berger M.M.
ISSN
1873-1244 (Electronic)
ISSN-L
0899-9007
Publication state
Published
Issued date
02/2017
Peer-reviewed
Oui
Volume
34
Pages
71-75
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Several trace elements are essential for immunity and wound healing, particularly after major burns. Continuous renal replacement therapy (CRRT), which is used to treat renal failure, causes significant trace elements losses. The aim of the present review is to update the current literature and draw attention to this type of complication, as copper deficiency is rarely suspected and diagnosed in clinical conditions and may occur in chronic critically ill patients.
This is an emblematic case report and review of literature.
Major copper and selenium deficiencies were documented in a patient with major burns complicated by renal failure. The main cause was effluent loss during prolonged CRRT. The copper deficit resulted in life-threatening bradycardia and the alteration of lipid metabolism with severe hypertriglyceridemia. The published data are scarce, but trace element losses with effluent have been previously documented, as has the affect of copper deficiency on cardiac rhythm.
The literature regarding the specific requirements for chronically critically ill patients is limited. During prolonged CRRT, copper and selenium levels decrease and probably should be monitored during prolonged therapy. Research in this area is required.

Pubmed
Web of science
Create date
16/01/2017 19:29
Last modification date
20/08/2019 15:35
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