Developmental constraints, innovations and robustness

Détails

Ressource 1 Sous embargo jusqu'au 01/02/2020.
Etat: Public
Version: Après imprimatur
Licence: Non spécifiée
ID Serval
serval:BIB_C0D33CFBC9BA
Type
Thèse: thèse de doctorat.
Collection
Publications
Titre
Developmental constraints, innovations and robustness
Auteur(s)
Liu Jialin
Directeur(s)
Robinson-Rechavi Marc
Détails de l'institution
Université de Lausanne, Faculté de biologie et médecine
Adresse
Department of Ecology and Evolution, Biophore, University of Lausanne, CH-1015 Lausanne, Switzerland
Statut éditorial
Acceptée
Date de publication
27/09/2019
Langue
anglais
Résumé
During my PhD, I have been working on Evo-Devo patterns (especially the debate around the
hourglass model) in transcriptomes, with an emphasis on adaptation. I have characterized
patterns in model organisms in terms of constraints and especially in terms of positive selection.
I found that the phylotypic stage (a stage in mid-embryonic development) is an evolutionary
lockdown, with stronger purifying selection and less positive selection than other stages in
terms of the evolution of protein sequences and of regulatory elements. To study the adaptive
evolution of gene regulation during development, I have developed a machine leaning based
in silico mutagenesis approach to detect positive selection on regulatory elements.
In addition to transcriptome evolution, I have been working on the tension between precision
and stochasticity of gene expression during development. More precisely, I have shown that
expression noise follows an hourglass pattern, with lower noise at the phylotypic stage. This
pattern can be explained by stronger histone modification mediated noise control at this stage.
In addition, I propose that histone modifications contribute to mutational robustness in
regulatory elements, and thus to conserved expression levels. These results provide insight into
the role of robustness in the phenotypic and genetic patterns of evolutionary conservation in
animal development
Open Access
Oui
Financement(s)
Université de Lausanne
Fonds national suisse / Projets
Création de la notice
21/10/2019 15:02
Dernière modification de la notice
26/11/2019 7:10
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