Sequential expression of genes involved in muscular dystrophies during human development

Détails

ID Serval
serval:BIB_C0B121E89E72
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Sequential expression of genes involved in muscular dystrophies during human development
Périodique
Morphologie
Auteur(s)
Durand  M., Suel  L., Barbet  J. P., Beckmann  J. S., Fougerousse  F.
ISSN
1286-0115 (Print)
Statut éditorial
Publié
Date de publication
06/2002
Volume
86
Numéro
273
Pages
9-12
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jun
Résumé
To elucidate the normal and pathophysiological roles of genes involved in the aetiology of muscular dystrophies, we studied the expression of dystrophin, four sarcoglycans, beta-dystroglycan and merosin during early human development. These proteins are expressed mainly in skeletal muscles while dystrophin, beta-dystroglycan, delta-sarcoglycan and merosin are in cardiac and smooth muscles. Dystrophin, beta-, delta-sarcoglycan and beta-dystroglycan are first expressed in the myotome at the 4th week of human embryogenesis, followed by gamma-sarcoglycan and merosin at the 6th week of development; alpha-sarcoglycan appears only at the level of the muscular fibre at the end of the embryonic period.
Mots-clé
Cytoskeletal Proteins/biosynthesis/genetics Dystroglycans Dystrophin/biosynthesis/genetics Embryonic and Fetal Development *Gene Expression Regulation, Developmental Gestational Age Heart/embryology Humans Laminin/biosynthesis/genetics Membrane Glycoproteins/biosynthesis/genetics Muscle Proteins/*biosynthesis/genetics Muscle, Skeletal/embryology/metabolism Muscular Dystrophies/*genetics Myocardium/metabolism Protein Structure, Tertiary Sarcoglycans
Pubmed
Création de la notice
25/01/2008 17:18
Dernière modification de la notice
03/03/2018 21:06
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