Trilateral retinoblastoma: neuroimaging characteristics and value of routine brain screening on admission.

Détails

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_C08FE35A11BE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Trilateral retinoblastoma: neuroimaging characteristics and value of routine brain screening on admission.
Périodique
Journal of Neuro-Oncology
Auteur(s)
Rodjan F., de Graaf P., Brisse H.J., Göricke S., Maeder P., Galluzzi P., Aerts I., Alapetite C., Desjardins L., Wieland R., Popovic M.B., Diezi M., Munier F.L., Hadjistilianou T., Knol D.L., Moll A.C., Castelijns J.A.
ISSN
1573-7373 (Electronic)
ISSN-L
0167-594X
Statut éditorial
Publié
Date de publication
2012
Volume
109
Numéro
3
Pages
535-544
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Trilateral retinoblastoma (TRb) is a rare disease associating intraocular retinoblastoma with intracranial primitive neuroectodermal tumor. Treatment is difficult and prognosis is poor. This multicenter study evaluates clinical findings and MR imaging characteristics of associated intracranial tumors in Rb patients. Clinical data of 17 patients (16 TRb and 1 quadrilateral Rb patients) included time intervals between Rb and TRb diagnosis and presence of baseline brain-imaging (BBI). Two reviewers reviewed all images individually and one reviewer per center evaluated their images. Consensus was reached during a joint scoring session. Studies were reviewed for tumor location, size and imaging characteristics (signal intensity (SI) on T1- and T2-weighted images, enhancement pattern and cystic appearance). Of 18 intracranial tumors, 78 % were located in the pineal gland and 22 % suprasellar. All tumors showed well-defined borders with mostly heterogenous enhancement (72 %) and isointense SI on T1- (78 %) and T2-weighted images (72 %) compared to gray matter. The majority of pineal TRbs showed a cystic component (57 %). TRb detected synchronously with the intraocular tumors on BBI (n = 7) were significantly smaller (P = 0.02), and mainly asymptomatic than TRb detected later on (n = 10). Overall, 5-year-survival of TRb patients detected on BBI was 67 % (95 % CI 29-100 %) compared to 11 % (95 % CI 0-32 %) for the group with delayed diagnosis. TRb mainly develops in the pineal gland and frequently presents with a cystic appearance that could be misinterpreted as benign pineal cysts. Routine BBI in all newly diagnosed Rb patients can detect TRb at a subclinical stage.
Pubmed
Web of science
Open Access
Oui
Création de la notice
04/10/2012 17:05
Dernière modification de la notice
20/08/2019 15:35
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