Renal handling of carnitine in ill preterm and term neonates

Détails

ID Serval
serval:BIB_C08DEF80EE62
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Renal handling of carnitine in ill preterm and term neonates
Périodique
Journal of Pediatrics
Auteur(s)
Zamora  S., Benador  N., Lacourt  G., Girardin  E.
ISSN
0022-3476
Statut éditorial
Publié
Date de publication
12/1995
Peer-reviewed
Oui
Volume
127
Numéro
6
Pages
975-8
Notes
Comparative Study
Journal Article --- Old month value: Dec
Résumé
OBJECTIVE: To investigate the renal handling of carnitine in preterm and term ill neonates. METHODS: We studied the fractional tubular reabsorption of carnitine and the proximal renal tubular function of infants in the first week of life who were receiving very little or no carnitine in their diets. RESULTS: Mean plasma levels were low: total carnitine was 16.4 +/- 7.0 mumol/L, free carnitine was 9.2 +/- 5.0 mumol/L, and acylcarnitine was 7.2 +/- 4.1 mumol/L. The most premature group of neonates (gestation age, 26 to 31 weeks) had a fractional tubular reabsorption rate of free carnitine of 94.3% +/- 3.3%, which was lower than in the other two groups (98.1% +/- 2.4% for gestational age 32 to 36 weeks, p = 0.001; and 99.2% +/- 0.6% for gestational age 37 to 42 weeks, p = 0.002). In all patients the fractional tubular reabsorption of acylcarnitine was lower than that of free carnitine, indicating possible tubular secretion of acylcarnitine. It correlated with the total plasma carnitine levels (r = 0.53; p = 0.002). The fractional tubular reabsorption of free carnitine also correlated with gestational age (r = 0.60; p < 0.001). CONCLUSIONS: Ill neonates have a fractional tubular reabsorption rate of free carnitine within the normal range. It increases with gestational age, and has the same maturation rate as the other known indexes of proximal tubular function.
Mots-clé
Carnitine/blood/*pharmacology/urine Creatinine/urine Fanconi Syndrome/diagnosis Gestational Age Glycosuria/urine Humans *Infant, Newborn *Infant, Premature Kidney/*drug effects Phosphates/urine
Pubmed
Web of science
Création de la notice
15/01/2008 15:28
Dernière modification de la notice
03/03/2018 21:06
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