Les contractions uterines lors du transfert embryonnaire: une entrave a l'implantation? [Uterine contractions at the time of embryo transfer: a hindrance to implantation?]

Détails

ID Serval
serval:BIB_C089EBCDD95E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Les contractions uterines lors du transfert embryonnaire: une entrave a l'implantation? [Uterine contractions at the time of embryo transfer: a hindrance to implantation?]
Périodique
Contracept Fertil Sex
Auteur(s)
Fanchin  R., Righini  C., Ayoubi  J. M., Olivennes  F., de Ziegler  D., Frydman  R.
ISSN
1165-1083
Statut éditorial
Publié
Date de publication
08/1998
Volume
26
Numéro
7-8
Pages
498-505
Notes
English Abstract
Journal Article --- Old month value: Jul-Aug
Résumé
OBJECTIVES: To investigate the hormonal control and the possible consequences of uterine contractions (UC) on IVF-ET outcome. MATERIALS AND METHODS: We studied prospectively 220 controlled ovarian hyperstimulation (COH) cycles for IVF-ET. Just before ET, women underwent 5-minute digital recordings of the uterus using US image analysis software for UC assessment. Plasma progesterone (P) and estradiol were measured. Four groups were defined according to UC frequency: < or = 3.0 (n = 53), 3.1 to 4.0 (n = 50), 4.1 to 5.0 (n = 43), and > 5.0 (n = 74) UC/minute, respectively. RESULTS: Patients, COH and embryology characteristics were comparable in all groups. Notwithstanding estradiol levels were not associated with UC characteristics, plasma P and UC frequency were negatively correlated (r = -0.34, P < 0.001). A stepwise decrease in clinical and ongoing pregnancy as well as implantation rates occurred from the lowest to the highest UC frequency groups (53%, 36%, 21%; 46%, 32%, 20%; 23%, 19%, 10%; and 14%, 11%, 4%; P < 0.001). Direction of UC did not affect ET outcome. CONCLUSIONS: The negative correlation between UC frequency and P levels supports the utero-relaxing properties of P. High frequency UC on the day of ET hinder IVF-ET outcome, possibly by expelling embryos out of the uterine cavity.
Mots-clé
Adult Biological Markers/blood *Embryo Implantation *Embryo Transfer Estradiol/blood Female Fertilization in Vitro Humans Ovulation Induction Progesterone/blood Prospective Studies *Uterine Contraction
Pubmed
Web of science
Création de la notice
28/02/2008 12:36
Dernière modification de la notice
03/03/2018 21:06
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