IRF4 and BATF are critical for CD8(+) T-cell function following infection with LCMV.

Détails

Ressource 1Télécharger: BIB_C07B5E63C74A.P001.pdf (945.26 [Ko])
Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_C07B5E63C74A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
IRF4 and BATF are critical for CD8(+) T-cell function following infection with LCMV.
Périodique
Cell Death and Differentiation
Auteur(s)
Grusdat M., McIlwain D.R., Xu H.C., Pozdeev V.I., Knievel J., Crome S.Q., Robert-Tissot C., Dress R.J., Pandyra A.A., Speiser D.E., Lang E., Maney S.K., Elford A.R., Hamilton S.R., Scheu S., Pfeffer K., Bode J., Mittrücker H.W., Lohoff M., Huber M., Häussinger D., Ohashi P.S., Mak T.W., Lang K.S., Lang P.A.
ISSN
1476-5403 (Electronic)
ISSN-L
1350-9047
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
21
Numéro
7
Pages
1050-1060
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish PDF : OPEN
Résumé
CD8(+) T-cell functions are critical for preventing chronic viral infections by eliminating infected cells. For healthy immune responses, beneficial destruction of infected cells must be balanced against immunopathology resulting from collateral damage to tissues. These processes are regulated by factors controlling CD8(+) T-cell function, which are still incompletely understood. Here, we show that the interferon regulatory factor 4 (IRF4) and its cooperating binding partner B-cell-activating transcription factor (BATF) are necessary for sustained CD8(+) T-cell effector function. Although Irf4(-/-) CD8(+) T cells were initially capable of proliferation, IRF4 deficiency resulted in limited CD8(+) T-cell responses after infection with the lymphocytic choriomeningitis virus. Consequently, Irf4(-/-) mice established chronic infections, but were protected from fatal immunopathology. Absence of BATF also resulted in reduced CD8(+) T-cell function, limited immunopathology, and promotion of viral persistence. These data identify the transcription factors IRF4 and BATF as major regulators of antiviral cytotoxic T-cell immunity.
Pubmed
Web of science
Open Access
Oui
Création de la notice
11/07/2014 17:50
Dernière modification de la notice
09/05/2019 0:42
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