Delivery systems and adjuvants for vaccination against HIV

Détails

ID Serval
serval:BIB_C0707493C4EF
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Delivery systems and adjuvants for vaccination against HIV
Périodique
EXS
Auteur(s)
Velin  D., Kraehenbuhl  J. P.
ISSN
1023-294X (Print)
Statut éditorial
Publié
Date de publication
2000
Volume
89
Pages
227-37
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review
Résumé
Epidemiological studies have revealed that HIV-1 infections occur through contact with contaminated blood or during unprotected vaginal or anal intercourse. Hence, to protect against HIV infection, vaccines should ideally induce both mucosal and systemic immune responses. We present a brief review of the different delivery systems and adjuvants which can be used to elicit mucosal immune responses. Oral or nasal administration of recombinant attenuated bacteria or viruses can induce both mucosal and systemic immune responses against the carried antigen. The oral delivery of mucosal adjuvants (such as cholera toxin) in association with antigens has been shown to enhance mucosal and systemic immune responses against them. Recently developed vaccination strategies using naked DNA or other antigen delivery systems are also discussed.
Mots-clé
AIDS Vaccines/*administration & dosage Adjuvants, Immunologic/administration & dosage Animals CD4-Positive T-Lymphocytes/immunology CD8-Positive T-Lymphocytes/immunology Drug Delivery Systems Female HIV Antibodies/metabolism HIV Infections/immunology/*prevention & control Humans Immunity, Mucosal Male Neutralization Tests Vaccines, DNA/administration & dosage Vaccines, Synthetic/administration & dosage
Pubmed
Création de la notice
25/01/2008 17:10
Dernière modification de la notice
03/03/2018 21:05
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