Morphology of popliteal lymph node responses in Brown-Norway rats.

Détails

ID Serval
serval:BIB_C048B14AC691
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Morphology of popliteal lymph node responses in Brown-Norway rats.
Périodique
Journal of Toxicology and Environmental Health
Auteur(s)
Brouland J.P., Verdier F., Patriarca C., Vial T., Descotes J.
ISSN
0098-4108 (Print)
ISSN-L
0098-4108
Statut éditorial
Publié
Date de publication
1994
Peer-reviewed
Oui
Volume
41
Numéro
1
Pages
95-108
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
The popliteal lymph node (PLN) assay has been proposed as a tool to predict in rodents those xenobiotics likely to induce autoimmune reactions in humans. To further validate this assay and to study the mechanisms involved, histologic changes in PLNs from rats injected with streptozotocin, diphenylhydantoin, pure acetone, or 50% ethanol were compared to a local graft-versus-host (GvH) reaction. This study suggests that routine histology of PLNs is instrumental to discard primary irritants. In addition, the hypothesis of a GvH-like mechanism in positive PLN responses is supported by the finding that the reference compounds streptozotocin and diphenylhydantoin produced histologic changes similar to a "true" local GvH reaction.
Mots-clé
Acetone/toxicity, Animals, Autoimmune Diseases/chemically induced, Ethanol/toxicity, Female, Graft vs Host Reaction, Knee, Lymph Nodes/drug effects, Lymph Nodes/immunology, Male, Organ Size/drug effects, Phenytoin/toxicity, Rats, Rats, Inbred BN, Streptozocin/toxicity
Pubmed
Création de la notice
13/10/2015 9:51
Dernière modification de la notice
20/08/2019 16:34
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