Thyroid hormone-aldosterone interaction on Na+ transport in toad bladder

Détails

ID Serval
serval:BIB_C045EB702525
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Thyroid hormone-aldosterone interaction on Na+ transport in toad bladder
Périodique
American Journal of Physiology
Auteur(s)
Rossier  B. C., Gaggeler  H. P., Brunner  D. B., Keller  I., Rossier  M.
ISSN
0363-6143
Statut éditorial
Publié
Date de publication
03/1979
Volume
236
Numéro
3
Pages
C125-31
Notes
Journal Article --- Old month value: Mar
Résumé
Repeated administration of thyroxine (T4) in vivo (2 microgram/100 g body wt for 6 days) lowered by 2.3 times (P less than 0.025, df = 18) the basal rate of Na+ transport measured by the short-circuit current (SCC) in vitro in the urinary bladder of the toad (Bufo marinus). This difference was not accounted for by a change in the plasma aldosterone concentration. Moreover the response of the SCC to aldosterone in vitro was markedly inhibited in bladders from T4-treated animals (P less than 0.001, df = 18). These findings raised the possibility of a direct interaction between thyroid hormone and aldosterone in the target cell. The effects of L-triiodothyronine (T3) and aldosterone were examined in vitro. T3 alone (60 nM) had no significant effect on the base-line SCC (deltamuA = -14 +/- 11 (SE) muA per hemibladder; P greater than 0.3, n = 10). By contrast, T3 (60 nM) inhibited the response of the SCC to aldosterone from 6 to 8 h after its addition (deltamuA = -98 +/- 19 muA per hemibladder; P less than 0.001, n = 10). The inhibition by T3 was present at 6 nM (P less than 0.01, n = 10) and became not significant at 0.6 nM. T3 had no significant effect on base-line or aldosterone-stimulated H+ transport. Thyroid hormone might therefore regulate the late response of the SCC to aldosterone at the level of its target cell.
Mots-clé
Aldosterone/blood/*metabolism/pharmacology Animals Biological Transport, Active/drug effects Bufo marinus/metabolism Drug Therapy, Combination Female Male Sodium/*metabolism Thyroxine/*pharmacology Triiodothyronine/*pharmacology Urinary Bladder/*metabolism
Pubmed
Web of science
Création de la notice
24/01/2008 14:01
Dernière modification de la notice
03/03/2018 21:05
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