Response of atrial natriuretic peptide to acute saline loading in essential hypertension

Détails

ID Serval
serval:BIB_C03E7567ACCB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Response of atrial natriuretic peptide to acute saline loading in essential hypertension
Périodique
American Journal of Physiology. Renal Physiology
Auteur(s)
Mimran  A., Nussberger  J., Ribstein  J., Waeber  B., Brunner  H. R.
ISSN
1931-857X
ISSN-L
1931-857X
Statut éditorial
Publié
Date de publication
12/1988
Volume
255
Numéro
6 Pt 2
Pages
F1085-90
Notes
Journal Article --- Old month value: Dec
Résumé
To further investigate the mechanism(s) of the exaggerated natriuretic response of hypertensives to volume expansion (VE; 1,800 ml iv isotonic saline over 3 h), the plasma levels of immunoreactive atrial natriuretic peptide (ANP) were measured in 11 normal subjects (NT) and 12 patients with mild essential hypertension (HT). NT and HT groups were similar with respect to age and basal levels of renin, aldosterone and ANP (34.5 +/- 5.5 in NT and 32.5 +/- 6.3 pg/ml in HT, mean +/- SE). In response to VE, ANP increased to the same extent in both groups (a change of 19.3 +/- 5.2 in NT and of 22.2 +/- 7.1 pg/ml in HT) despite the finding of an exaggerated natriuretic response to VE in essential hypertension (36 +/- 3.5 in NT and 54.9 +/- 6.3 nmol/3 h in HT, P less than 0.02). In addition, the fall in hematocrit and serum protein associated with saline infusion was less marked in HT than NT. The change in ANP induced by VE was inversely correlated with the percent fall in hematocrit and the increment in the fractional excretion of sodium in both groups. These observations suggest that ANPs may participate in the control of the renal response to isotonic VE; however they do not support an unequivocal influence of ANP in the exaggerated natriuretic response to VE of patients with essential hypertension.
Mots-clé
Adult Aldosterone/blood Atrial Natriuretic Factor/blood/*secretion Blood Pressure Creatinine/metabolism Female Glomerular Filtration Rate Heart Rate Humans Hypertension/blood/*physiopathology Male Middle Aged Potassium/blood/urine Reference Values Renin/blood Sodium/blood/urine Sodium Chloride/*pharmacology
Pubmed
Web of science
Création de la notice
05/03/2008 17:41
Dernière modification de la notice
03/03/2018 21:05
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